文章摘要

肺鳞状细胞癌EGFR/ALK的基因状态

作者: 1庄武, 2钟礼花, 2陈芳芳, 2陈燕坪, 1黄韵坚, 1黄章洲, 2卢建平, 2王晓江, 2师怡, 2林贤东, 2许春伟, 2陈刚
1 福建医科大学附属福建省肿瘤医院胸部肿瘤内科，福州 350014
2 福建医科大学附属福建省肿瘤医院病理科，福州 350014
通讯: 黄韵坚 Email: 13805099580@126.com
许春伟 Email: xuchunweibbb@163.com
陈刚 Email: naichengang@126.com
DOI: 10.3978/j.issn.2095-6959.2017.05.019
基金: 国家临床重点专科建设项目, 2013 福建省科技厅引导性项目, 2015Y0011，2016Y0019

摘要

目的：探讨肺鳞状细胞癌各亚型中EGFR和ALK的基因状态。方法：应用ARMS方法检测肺鳞状细胞癌石蜡组织中EGFR基因突变和ALK融合基因情况。结果：218例肺鳞状细胞癌样本中，EGFR基因突变率为4.59%(10/218)，19del和L858R各为2.29%(5/218)。ALK融合基因阳性率为6.14%(7/114)。结论：肺鳞状细胞癌存在一定比例EGFR基因突变和ALK融合基因阳性，肺鳞状细胞癌EGFR基因和ALK融合基因常规检测不可忽视。
关键词： 鳞状细胞癌 EGFR基因 ALK基因 突变率

EGFR/ALK gene status of lung squamous cell carcinoma

Authors: 1ZHUANG Wu, 2ZHONG Lihua, 2CHEN Fangfang, 2CHEN Yanping, 1HUANG Yunjian, 1HUANG Zhangzhou, 2LU Jianping, 2WANG Xiaojiang, 2SHI Yi, 2LIN Xiandong, 2XU Chunwei, 2CHEN Gang
1 Department of Medical Thoracic Oncology, Fujian Cancer Hospital, Fujian Medical University, Fuzhou 350014, China
2 Department of Pathology, Fujian Cancer Hospital, Fujian Medical University, Fuzhou 350014, China

CorrespondingAuthor: HUANG Yunjian Email: 13805099580@126.com

DOI: 10.3978/j.issn.2095-6959.2017.05.019

Abstract

Objective: To investigate the mutations of EGFR gene and ALK fusion gene in lung squamous cell carcinoma. Methods: The ARMS method was used to detect the tissues in 218 patients of lung squamous cell carcinoma with paraffin tissue EGFR gene mutation and ALK fusion gene. Results: The total mutation rate in 218 patients of squamous cell carcinoma was 54.71%(151/276). EGFR gene mutation rate was 2.29% (5/218), which was both found in 19del and L858R, ALK fusion gene positive rate was 6.14% (7/114). Conclusion: There are a certain proportion of EGFR gene mutation and ALK fusion gene in lung squamous cell carcinoma, and the detection the EGFR gene mutation and ALK fusion gene can not be ignored in squamous cell carcinoma.

文章选项

下载引文

分享