文章摘要

生物钟基因Timeless及与肿瘤关系的研究进展

作者: 1张金玲, 1吴超, 2杨盛力
1 临沂市莒南县人民医院消化内科，山东 临沂 276600
2 华中科技大学同济医学院附属协和医院肿瘤中心，武汉 430022
通讯: 杨盛力 Email: 576150913@qq.com
DOI: 10.3978/j.issn.2095-6959.2017.05.033
基金: 中央高校基本科研业务费专项资金：华中科技大学自主创新基金, 2016YXM241 中国肝炎防治基金会–天晴肝病研究基金, TQGB2017005

摘要

生物钟基因的功能不仅局限于调节生物节律，更与细胞内DNA的修复、细胞的增殖等一系列过程相关联，Timeless是生物钟基因成员之一，对Timeless基因的研究起步较晚。近年来研究发现生物钟基因在多种肿瘤中普遍存在表达异常，而对Timeless研究较少。
关键词： Timeless 生物钟 基因 肿瘤

Research progress in relationship between Timeless and tumor

Authors: 1ZHANG Jinling, 1WU Chao, 2YANG Shengli
1 Department of Gastroenterology, People’s Hospital of Junan Linyi City, Linyi Shandong 276600
2 Cancer Center of Xiehe Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology, Wuhan 430022, China

CorrespondingAuthor: YANG Shengli Email: 576150913@qq.com

DOI: 10.3978/j.issn.2095-6959.2017.05.033

Abstract

The function of clock genes is not only confined to adjust biological rhythm, but also has a great relationship with cell proliferation and DNA repair in cells. Timeless is a member of clock genes, but the study on Timeless started late relatively. In recent years, some study found that the circadian clock genes have an abnormal expression in a variety of tumors. But among these study, researches on Timeless are less. Therefore, this article summarized the domestic and foreign researches on Timeless for a review, and discussed the relationship between Timeless and tumor.

文章选项

下载引文

分享