Objective: To determine the influence of Patient-centered systematic health Education on osteoporosis knowledge, self-efficacy and bone mineral density (BMD) of osteoporosis patients during peri- or post-menopause period. Methods: A total of 156 osteoporosis patients during peri- or post-menopause period were divided into an observation group and a control group according to the random numbers generated from the computer. The control group adopted routine health education, while the observation group adopted Patient-centered systematic health Education. The changes of osteoporosis knowledge test (OKT) scores, osteoporosis self-efficacy scale (OSES) scores and BMD levels of the two groups before intervention and 6 months after intervention were collected and compared. Results: The total OKT scores and the scores of various dimensions, the total OSES scores and the scores of various dimensions, and the BMD levels of L1–L4 lumbar vertebrates and the left os femoris of the two groups after intervention were evidently higher than those before intervention. The scores of above items of the observation group were evidently higher than those of the control group; the differences were of statistical significance (P<0.05). Conclusion: Patient-centered systematic health education can significantly improve the level of illness cognition, self-efficacy in coping with illness and BMD level of the osteoporosis patients during Peri-menopausal Period or Post-menopause Period. This method can positively prevent fracture and improve quality of life.