文章摘要

促红细胞生成素肝细胞激酶受体与ephrin配体及其信号转导在肿瘤中的研究进展

作者: 1殷灵瑜, 1赵耀, 2李洪春, 2马萍, 2李世宝
1 徐州医科大学医学技术学院，江苏 徐州 221000
2 徐州医科大学 附属医院检验科，江苏 徐州 221000
通讯: 李世宝 Email: sdjnshlb@163.com
DOI: 10.3978/j.issn.2095-6959.2017.05.029
基金: 江苏省自然科学基金, BK20160233

摘要

促红细胞生成素肝细胞激酶(erythropoietin producing hepatocyte kinase，Eph)受体及其膜结合配体ephrin是最大的受体酪氨酸激酶(receptor tyrosine kinases，RTKs)家族，其不仅调节生物体的多种生理功能，而且参与多种疾病的发生发展过程。近年来，已有越来越多的证据表明肿瘤的发生发展与Eph家族成员异常表达密切相关。
关键词： 促红细胞生成素肝细胞激酶 ephrin 信号转导

Research progress in erythropoietin producing hepatocyte kinase receptor and ephrin ligand as well as their signal transduction in cancer

Authors: 1YIN Lingyu, 1ZHAO Yao, 2LI Hongchun, 2MA Ping, 2LI Shibao
1 School of Medical Technology, Affiliated Hospital, Xuzhou Medical University, Xuzhou Jiangsu 221000
2 Department of Clinical Laboratory, Affiliated Hospital, Xuzhou Medical University, Xuzhou Jiangsu 221000, China

CorrespondingAuthor: LI Shibao Email: sdjnshlb@163.com

DOI: 10.3978/j.issn.2095-6959.2017.05.029

Abstract

Erythropoietin producing hepatocyte kinase (Eph) receptors and membrane binding ephrin ligands are the largest family of receptor tyrosine kinase, which not only regulate a great deal of physiological functions in organisms, but also participate in the occurrence and development of a variety of diseases. In recent years, there is more and more evidence that tumor development and Eph family members are closely related to abnormal expression.

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