椎管内炎症性肌纤维母细胞性肿瘤1例临床病理分析及文献复习
| 作者: |
1李青,
1邓星辉,
1刘琼茹,
2崔恩铭,
2陈相猛,
2黄列彬
1 中山大学附属江门市中心医院 病理科，广东 江门 529000 2 中山大学附属江门市中心医院 放射科，广东 江门 529000 |
| 通讯: |
李青
Email: 32242930@qq.com |
| DOI: | 10.3978/j.issn.2095-6959.2015.02.035 |
摘要
目的：探讨椎管内炎性肌纤维母细胞瘤(inflammatory myofibroblastic tumor，IMT)的临床病理特 征、免疫表型和鉴别诊断。方法：对1例椎管内IMT进行临床病理分析及免疫组织化学研究，并复 习相关文献。结果：术前MR显示C7-T8椎体水平硬膜下软组织肿块形成。镜下示肿瘤组织主要由 梭形的纤维母细胞和肌纤维母细胞混合性增生构成，间质可见大量成熟的浆细胞、淋巴细胞为主 的炎细胞浸润，免疫组化显示梭形细胞区表达vimentin、SMA及calponin部分阳性，但ALK阴性。 术后随访3及6个月未见复发迹象。结论：椎管内IMT是一种少见疾病，临床与影像学表现缺乏特 异性，易与发生于脊椎的神经鞘瘤、浆细胞瘤等混淆。
关键词：
椎管
炎症性肌纤维母细胞瘤
病理学
预后
Clinicopathologic analysis of intraspinal inflammatory myofibroblastic tumor (IMT): a case report and literature reviews
CorrespondingAuthor: LI Qing Email: 32242930@qq.com
DOI: 10.3978/j.issn.2095-6959.2015.02.035
Abstract
Aim: To evaluate the clinicopathological features, immunophenotype and differential diagnosis of intraspinal inflammatory myofibroblastic tumor (IMT). Methods: One case of intraspinal IMT was studied by clinicopathological analysis and immunohistochemistry, and the related literature was reviewed. Results: Preoperative MR revealed a subdural mass from C7 to T8 level of spinal cord. Microscopically, the tumor was characterized by mixed arrangement of fibroblast and myofibroblast, infiltration of inflammatory cells including mature plasmecytes, lymphocytes in the stroma. Immunohistochemically, the spindle cells were positive for vimentin, and positive for SMA and calponin partially, but not ALK. No recurrence was found after follow-ups for 3 and 6 months. Conclusion: Intraspinal IMT is a rare tumor without any special radiological and clinical appearance. It should be distinguished from other diseases such as neurilemmoma and plasmacytoma in the spine.