The inflammation theory for coronary heart disease is gradually recognized. Many basic and clinical studies confirmed that the high-sensitivity C-reactive protein (hs-CRP) is not only a non-specific marker for inflammation, but it also directly involves in the pathological process of cardiovascular diseases. It plays a significant role in guiding the diagnosis and treatment of coronary heart disease, especially in predicting the risk for coronary heart disease in healthy people. The relation between the hs-CRP and coronary heart disease, as well as pathogenic mechanism of hs-CRP in coronary heart disease is reviewed in this article.