硫化氢对神经退行性疾病保护作用的研究进展
| 作者: |
1李文婷,
1邹伟
1 南华大学附属南华医院神经内科,湖南 衡阳 421002 |
| 通讯: |
邹伟
Email: zouwei415@163.com |
| DOI: | 10.3978/j.issn.2095-6959.2013.01.015 |
摘要
硫化氢(hydrogen sulfide, H2S)一直被认为是一种有毒气体。近年来,越来越多的研究显示H2S在哺乳动物体内可以调节及参与一定范围的生理和病理过程。H2S在中枢神经系统中扮演着重要的角色。H2S具有抗氧化应激、抗凋亡以及抗炎的作用,而这些生理学意义对研究防治包括阿尔茨海默病、帕金森氏病在内的神经退行性疾病有着重要的启示。
关键词：
硫化氢
神经退行性疾病
氧化应激
凋亡
神经炎症
Progress in research on protective effect of hydrogen sulfide on neurodegenerative disease
CorrespondingAuthor: ZOU Wei Email: zouwei415@163.com
DOI: 10.3978/j.issn.2095-6959.2013.01.015
Abstract
For hundreds of years, hydrogen sulfide H2S has been considered to be a toxic gas. In recent years, more and more studies have shown that H2S in the mammalian body can be adjusted and it involves in a range of physiological and pathological processes. H2S plays an important role in the central nervous system. H2S shows effects of anti-oxidant, anti-apoptosis and anti-inflammation, which might be significant in prevention of neurodegenerative disease, such Alzheimer's disease and Parkinson's disease.