MicroRNA与心血管重构
| 作者: |
1邓璧,
1李元建
1 中南大学药学院药理学系，长沙 410078 |
| 通讯: |
李元建
Email: yuan_jianLi@yahoo.com |
| DOI: | 10.3978/j.issn.2095-6959.2013.03.009 |
摘要
MicroRNA为短小(18~25个核苷酸组成)单链非编码RNAs，几乎参与所有疾病的病理生理过程。心血管重构是多种心血管疾病发生与发展的病理基础，而microRNA在心血管重构中起重要调控作用。在心肌性疾病中，microRNA通过多种机制影响心肌细胞肥大、凋亡和间质纤维化；在血管重构性疾病中，不同microRNA通过多条信号通路调节血管平滑肌细胞增殖和分泌。
关键词：
microRNA；心肌重构；血管重构
MicroRNA and cardiovascular remodeling
CorrespondingAuthor: LI Yuanjian Email: yuan_jianLi@yahoo.com
DOI: 10.3978/j.issn.2095-6959.2013.03.009
Abstract
MicroRNA is a short (18–25 nucleotides) and single-stranded non-coding RNA which is involved in almost all pathological and physiological process of diseases. Cardiovascular remodeling is the pathological basis of development of multiple cardiovascular diseases, in which microRNA plays an important role. In cardiac diseases, microRNAs affect myocardial cell hypertrophy, apoptosis, and interstitial fibrosis through a variety of mechanisms. In vascular remodeling diseases, microRNAs regulate proliferation and secretion of vascular smooth muscle cells through multiple signaling pathways.