AMCase, eotaxin-3及IL-13在支气管哮喘发病机制中的作用
| 作者: |
1吴雄英,
1曹志伟
1 中国医科大学附属盛京医院耳鼻咽喉科，沈阳 110004 |
| 通讯: |
曹志伟
Email: wuxiongying20970@163.com |
| 基金: | 国家自然科学基金, 81200730 辽宁省科技计划项目, 2011404013-10 辽宁“百千万人才工程”项目, 2011921042 |
摘要
支气管哮喘是最常见的过敏性疾病，它是多种细胞参与的慢性气道炎症。酸性哺乳动物壳多糖酶（acid mammals chitinase，AMCase）作为壳多糖酶家族重要成员之一，与其下游信号分子嗜酸性粒细胞趋化因子-3一起，通过依赖白细胞介素13诱导的Th2炎症途径而发挥作用，近年来已成为哮喘研究中的热点。
关键词：
支气管哮喘；酸性哺乳动物壳多糖酶；嗜酸性粒细胞趋化因子；白细胞介素13
Role of AMCase, eotaxin-3 and IL-13 in the pathogenesis of asthma
CorrespondingAuthor: CAO Zhiwei Email: wuxiongying20970@163.com
Abstract
Asthma is the most common allergic disease, which is the inflammation of chronic airway involved a variety of cells. As an important member of the chitinase family, acid mammals chitinase (AMCase) together with the downstream signal molecule eosinophils chemokine-3 (eotaxin-3) plays a role in Th2 inflammation through an IL-13-dependent mechanism, which is attracting attention recently in the study of asthma.