文章摘要

FABP4在肥胖急性髓系白血病中的研究进展

作者: 1赵苓杉, 1张学美
1 昆明医科大学第一附属医院血液科,云南省血液病研究中心,昆明 650032
通讯: 张学美 Email: 1751878618@qq.com
DOI: 10.3978/j.issn.2095-6959.2020.10.040
基金: 云南省卫生科技计划项目(2018NS0130)。

摘要

急性髓系白血病(acute myeloid leukemia,AML)是一种高度恶性的血液系统肿瘤,其病因和复发困扰着我们。当前研究发现肥胖与AML的发生发展密切有关,肥胖AML患者的存活率较非肥胖患者低。脂肪酸结合蛋白4(fatty acid-binding protein 4,FABP4)作为提示肥胖有利于AML细胞生长的脂肪因子,可能是肥胖AML患者较非肥胖患者存活率低的原因之一。FABP4可通过MAPK,IL-6/STAT3信号转导通路等影响细胞增殖、存活和分化,下调或抑制FABP4的表达,抑制AML细胞。总的来说,FABP4可能作为肥胖AML发病及预后的重要因子,为临床治疗提供新的靶点。
关键词: 急性髓系白血病;肥胖;脂肪因子;脂肪酸结合蛋白4

Research progress of FABP4 in obese acute myeloid leukemia

Authors: 1ZHAO Lingshan, 1ZHANG Xuemei
1 Department of Hematology, First Affiliated Hospital of Kunming Medical University, Yunnan Blood Disease Research Center, Kunming 650032, China

CorrespondingAuthor: ZHANG Xuemei Email: 1751878618@qq.com

Foundation: This work was supported by Yunnan Health Science and Technology Plan Project, China (2018NS0130).

Abstract

Acute myeloid leukemia (AML), as a highly malignant hematological tumor, still plagues us with its etiology and recurrence; current studies have found that obesity is closely related to the development of acute myeloid leukemia, and the survival rate of obese acute myeloid leukemia patients is lower than that of non-obese patients. Fatty acid-binding protein 4 (FABP4), as a fat factor suggesting that obesity is beneficial to the growth of AML cells, may be one of the reasons for the low survival rate of obese AML patients compared with non-obese patients. FABP4 can pass MAPK, IL-6/STAT3 signaling pathway. Etc. affects cell proliferation, survival and differentiation, and inhibits AML cells by down-regulating or inhibiting the expression of FABP4. In general, FABP4 may be an important factor in the pathogenesis and prognosis of obese acute myeloid leukemia, providing a new target for clinical treatment.
Keywords: acute myeloid leukemia; obesity; adipokines; fatty acid-binding protein 4