文章摘要

孕产妇血清Hcy、叶酸、VB12和血脂水平对重度子痫前期早期诊断的价值

作者: 1张晓瑜, 1杨艳, 1樊萍
1 重庆市第五人民医院妇产科,重庆 400062
通讯: 樊萍 Email: 32532887@qq.com
DOI: 10.3978/j.issn.2095-6959.2020.09.014

摘要

目的:研究孕产妇血清同型半胱氨酸(homocysteine,Hcy)、叶酸、维生素B12(vitamin B12,VB12)和血脂水平对重度子痫前期的预测价值。方法:回顾性分析2018年6月至2019年12月于重庆市第五人民医院定期规律产检并分娩的120例孕产妇。按照是否确诊为重度子痫前期,分为研究组及对照组,每组各60例。于妊娠早期(孕周11~12周)检测比较产妇清晨血清Hcy、叶酸、VB12、总胆固醇(total cholesterol,TC)、三酰甘油(triglyceride,TG)、脂蛋白a(lipoprotein a,Lip a)、低密度脂蛋白(low density lipoprotein,LDL)、高密度脂蛋白(high density lipoprotein,HDL)、载脂蛋白A1(apolipoprotein A1,Apo-A1)及载脂蛋白B(apolipoprotein B,Apo-B)水平,采用logistic回归分析差异有统计学意义的指标,并分析其预测重度子痫前期发生的意义。结果:研究组孕产妇的年龄、体重指数及初产比例显著高于对照组孕产妇,差异均有统计学意义(P<0.05);研究组孕产妇血清Hcy,TG,Apo-B水平显著高于对照组,差异均有统计学意义(P<0.05);研究组孕产妇血清叶酸水平显著低于对照组,差异有统计学意义(P<0.05);logistic回归分析发现,年龄、体重指数及血清Hcy水平为孕产妇重度子痫前期发生的独立危险因素。结论:年龄、体重指数及血清Hcy水平为孕产妇重度子痫前期发生的独立危险因素,联合检测孕产妇血清Hcy、叶酸、VB12及血脂水平能够协助早期诊断重度子痫前期,值得临床推广。
关键词: 重度子痫前期;同型半胱氨酸;叶酸;VB12;血脂

Value of maternal serum Hcy, folic acid, VB12 and lipid levels in early diagnosis of severe preeclampsia

Authors: 1ZHANG Xiaoyu, 1YANG Yan, 1FAN Ping
1 Department of Obstetrics and Gynecology, Chongqing Fifth People’s Hospital, Chongqing 400062, China

CorrespondingAuthor: FAN Ping Email: 32532887@qq.com

Abstract

Objective: To study the predictive value of maternal serum homocysteine (Hcy), folic acid, vitamin B12 (VB12) and lipid levels for severe preeclampsia. Methods: Retrospective analysis was performed on 120 pregnant women who had regular labor and delivery in our hospital from June 2018 to December 2019. Depending on whether or not severe preeclampsia is diagnosed, the pregnant woman were divided into a study group and a control group, 60 cases in each group. Serum Hcy, folic acid, VB12, total cholesterol (TC), triglyceride (TG), lipoprotein a (Lip a), low density lipoprotein (LDL), high density lipoprotein (HDL), apolipoprotein A1 (Apo-a1) and apolipoprotein B (Apo-B) were detected and compared in the first trimester (11 to 12 weeks); the statistically significant indicators were analyzed by logistic regression and the significance of predicting the occurrence of severe preeclampsia was analyzed. Results: The age, body mass index and ratio of first birth of pregnant women in the study group was significantly higher than that in the control group, with statistically significant differences (P<0.05); the serum Hcy, TG, Apo-B levels in the study group were significantly higher than those in the control group, with statistically significant differences (P<0.05); the serum folic acid levels in the study group were significantly lower than that in the control group, with statistically significant differences (P<0.05); logistic regression analysis found that Age, body mass index and serum Hcy level were independent risk factors for severe preeclampsia in pregnant women. Conclusion: Age, body mass index, and serum Hcy level were independent risk factors for severe preeclampsia in pregnant women. A combination detection of serum Hcy, folic acid, VB12 and lipid levels in pregnant women can assist in the early diagnosis of severe preeclampsia, which is worthy of clinical promotion.
Keywords: severe preeclampsia; homocysteine; folic acid; vitamin B12; lipid