文章摘要

突变型p53 调节蛋白在淋巴瘤中作用的研究进展

作者: 1,2吴仕收, 2于国华
1 烟台市莱山区观海路346号滨州医学院,山东 烟台 264003
2 烟台毓璜顶医院病理科,山东 烟台 264000)
通讯: 于国华 Email: ygh0535@hotmail.com
DOI: 10.3978/j.issn.2095-6959.2020
基金: 烟台市重点研发项目(2017WS101)。

摘要

肿瘤抑制因子p53在维持细胞正常生长及抑制细胞恶性增殖过程发挥重要作用,当发生突变后形成突变型p53,其表达产物MTP53 (mutant type P53)即失去原有的抑癌作用导致细胞内信号通路紊乱,P53扮演的控制细胞增殖和凋亡得开关作用失活,细胞发生癌变,此过程受多种调节蛋白的影响。
关键词: 突变型肿瘤抑制因子p53;调节蛋白;淋巴瘤;代谢

Research advance on the role of mutant type p53 regulatory protein in lymphoma

Authors: 1,2WU Shishou, 2YU Guohua
1 Department of Clinical Medcine, Binzhou Medical University, Yantai Shandong 264003, China
2 Department of Pathology, Yantai Yuhuangding Hospital, Yantai Shandong 264000, China

CorrespondingAuthor: YU Guohua Email: ygh0535@hotmail.com

Foundation: This work was supported by the Yantai Key Research and Development Project, China (2017WS101).

Abstract

Tumor suppressor p53 plays an important role in maintaining normal cell growth and inhibiting cell malignant proliferation. When mutant type p53 is formed, its expression product, mutant type P53 loses original anti-tumor effect and leads to the disorder of intracellular signal pathway. P53 acts as a switch to control cell proliferation and apoptosis, and cells become cancerous, which is affected by a variety of regulatory proteins.
Keywords: mutant type p53; regulatory protein; lymphoma