文章摘要

1例阴茎丛状神经鞘瘤的临床病理特征及文献复习

作者: 1赵 涓涓, 1张 弘, 1雷 露, 1吕 思佳
1 鄂州市中心医院病理科,湖北 鄂州 436000
通讯: 赵 涓涓 Email: viewcat@163.com
DOI: 10.3978/j.issn.2095-6959.2020.04.043

摘要

采用光镜及免疫组织化学(immunohistochemistry,IHC)等方法对1例阴茎丛状神经鞘瘤进行临床、病理回顾性分析。患者因阴茎无痛性肿块入院,镜下见肿瘤由纤维结缔组织间隔为多结节,结节内由束状区(Antoni A区)的施万细胞构成,可见栅栏状结构,周围可见少许黏液样间质。瘤细胞表达Vimentin,S-100,不表达胶质纤维酸性蛋白(glial fibrillary acidic portein,GFAP),周围黏液样间质表达CD34。阴茎丛状神经鞘瘤少见,临床诊断困难,明确诊断需要病理广泛取材及IHC检测。治疗以手术切除为主,预后好。
关键词: 阴茎;丛状神经鞘瘤;泌尿生殖系肿瘤

Clinical and pathological features of plexiform schwannoma of the penis: A case report

Authors: 1ZHAO Juanjuan, 1ZHANG Hong, 1LEI Lu, 1LÜ Sijia
1 Department of Pathology, Ezhou Central Hospital, Ezhou Hubei 436000, China

CorrespondingAuthor:ZHAO Juanjuan Email: viewcat@163.com

Abstract

A case of plexiform schwannoma of the penis was retrospectively analyzed by light microscopy and immunohistochemistry (IHC). The patient was hospitalized for painless mass of the penis. Microscopically, the tumor was composed of multiple nodules with fibrous connective tissue septum. The nodules were composed of Schwann cells in the bundle area (Antoni A), with palisade structure and a little mucoid stroma around them. The tumor cells expressed Vimentin and S-100, but not glial fibrillary acidic portein (GFAP). CD34 was expressed in the surrounding mucoid stroma. Plexiform schwannoma of the penis is rare and difficult to diagnose clinically. A definite diagnosis requires extensive pathological sampling and IHC detection. Surgical resection is the main treatment with good prognosis.
Keywords: penis; plexiform schwannoma; genitourinary tumor