文章摘要

1例EGFR敏感突变局部晚期肺鳞癌病例报告及文献复习

作者: 1詹 志翔, 1冯 海林, 1廖 凌峰
1 信阳市中心医院肿瘤内一科,河南 信阳 464000
通讯: 詹 志翔 Email: 153169758@qq.com
DOI: 10.3978/j.issn.2095-6959.2020.01.044

摘要

报告1例信阳市中心医院经病理确诊、EGFR检测敏感突变的局部晚期肺鳞癌,该患者为一老年男性,不能耐受同步放化疗后序贯接受表皮生长因子受体-酪氨酸激酶抑制剂(epidermal growth factor receptor-tyrosine kinase inhibitors,EGFR-TKIs)治疗,效果显著,无进展生存期(progression-free survival,PFS)达19个多月,后期病情进展后再次行基因检测(液态活检),发现T790M突变,给予第3代TKI奥希替尼治疗后仍然有效。对于III期不可切除的局部晚期肺鳞癌,EGFR基因检测非常重要,同步放化疗后序贯EGFR-TKIs分子靶向药物的治疗模式,可延长此类患者的生存时间和提高生活质量。
关键词: EGFR敏感突变;局部晚期肺鳞癌; 靶向治疗

A case of locally advanced lung squamous cell carcinoma with EGFR sensitive mutation and literature review

Authors: 1ZHAN Zhixiang, 1FENG Hailin, 1LIAO Lingfeng
1 Department of Oncology, Xinyang Central Hospital, Xinyang Henan 464000, China

CorrespondingAuthor:ZHAN Zhixiang Email: 153169758@qq.com

Abstract

A case of locally advanced lung cancer confirmed by pathology in Xinyang Central Hospital was reported. The patient was an elderly male who could not tolerate sequential EGFR-TKI treatment after synchronous radiotherapy and chemotherapy. Progression-free survival (PFS) reached more than 19 months. Gene detection (liquid biopsies) was performed again after the later stage of the disease. It was found that T790M mutation was still effective after treatment with the third generation TKI dovitinib. For stage III unresectable locally advanced lung cancer, EGFR gene detection is very important. Sequential EGFR-TKIs molecular targeted drugs after synchronous radiotherapy and chemotherapy can prolong the survival time and improve the quality of life of these patients.
Keywords: EGFR sensitive mutation; locally advanced lung squamous cell carcinoma; targeted therapy