Objective: With the detection rate of the patients with lung cancer as second primary malignancy (LCSPM) gradually increased, clinicians are still lack of sufficient attention and recognition to these patients. In this study, clinical characters, tumor location and prognosis of these patients with LCSPM were retrospectively analyzed, in order to provide some research evidence to guide clinical practice. Methods: We collected cases of LCSPM in Shanghai Chest Hospital, Shanghai Jiao Tong University, from January 2012 to February 2016. The chi-square test was used for categorical variables, and survival curves were calculated by the Kaplan-Meier method, and then we obtained the influence factors for survival and the survival rate of LCSPM patients. Results: Breast, upper aerodigestive, thyroid and colorectum were the most prevalent initial primary tumors; the median interval between the two tumors was 72 months; surgery and stage of lung cancer were factors that affect the survival of LCSPM patients. Conclusion: Other organs should not be ignored in the follow-up of patients with a history of cancer. Early detection for surgical opportunity of lung cancer can extend the survival of the LCSPM patients.