Neuropathy pain is a kind of pain due to injury or disease to the body of sensory nerve system. Sonic hedgehog (Shh) signal transduction pathway is a classic control signal transduction pathways in embryonic development. And it be found that the signaling pathways involved in the development of the nervous system model in mature steady state, so is becoming a hot spot in the field of new signal transduction. Novel studies have demonstrated that the Shh pathway is associated with pain sensitization in neuropathy pain. And its mechanism maybe about astrocyte activation, inflammation factors and the change of the synaptic plasticity.