文章摘要

神经营养因子和生长因子在神经干细胞中的研究进展

作者: 1曾维军, 1,2周文胜, 2王佳
1 南华大学附属省马王堆医院神经内科
2 湖南省老年医院神经疾病研究室，长沙 410001
通讯: 曾维军 Email: 389779844@qq.com
周文胜 Email: zhouwensheng@163.com
王佳 Email: 13875888342@163.com
DOI: 10.3978/j.issn.2095-6959.2015.03.029

摘要

神经营养因子(neurotrophic factors，NF)包括神经生长因子(nerve growth factor，NGF)、脑源性神 经营养因子(brain-derived neural neurotrophic factor，BDNF)等。生长因子(growth factors，GF)家 族成员有酸性成纤维细胞生长因子(acidic fibroblast growth factor，aFGF)、碱性成纤维细胞生长 因子(basic fibroblast growth factor，bFGF)、血管内皮生长因子(vascular endothelial growth factor， VEGF)等，两大家族均对神经系统的发育以及维持神经干细胞(neural stem cells，NSCs)的存活、促 进其增殖、分化并诱导其定向迁移等众多方面发挥着重要作用。本文简要概括介绍NF中的重要成 员之一脑源性神经营养因子，GF家族中的重要成员VEGF和bFGF对NSCs的影响。
关键词： 神经干细胞 神经营养因子 生长因子 脑源性神经营养因子 血管内皮生长因子 碱性成纤维 细胞生长因子

Neurotrophic factors and growth factors in the research progress of neural stem cells

Authors: 1ZENG Weijun, 1,2ZHOU Wensheng, 2WANG Jia
1 Department of Neurology, Hunan Mawangdui Hospital Affiliated to University of South China
2 Institute of Neurology Disease, Hunan Geriatric Hospital, Changsha 410001, China

CorrespondingAuthor: ZENG Weijun Email: 389779844@qq.com

DOI: 10.3978/j.issn.2095-6959.2015.03.029

Abstract

Neurotrophic factor including nerve growth factor (NGF), brain-derived neural neurotrophic factor (BDNF) and so on. Members of the family of growth factors (GF) with acidic fibroblast Growth factor (aFGF), basic fibroblast growth factor (bFGF) and vascular endothelial growth factor (VEGF) and so on, the two families are on the nervous system development and sustenance of Neural stem cells, they play an important role in many areas, such as keep the development of nervous system, promote the survival, proliferation, differentiation and induce the directional migration of neural stem cells (NSCs). This article briefly summarizes the effects of BDNF, VEGF, bFGF on neural stem cells.

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