抵抗素样分子β研究进展
| 作者: |
1李林伟,
2戴爱国,
2蒋永亮
1 南华大学附属湖南省马王堆医院，长沙 410016 2 湖南省老年医院，长沙 410016 |
| 通讯: |
戴爱国
Email: daiaiguo2003@163.com |
| DOI: | 10.3978/j.issn.2095-6959.2014.06.037 |
| 基金: | 国家自然科学基金资助项目, 81270118 |
摘要
抵抗素样分子β(Resistin-like molecules β，RELMβ)起初作为一种肠源性分泌蛋白，其在肠道增生及 局部免疫中起到十分重要的作用。随着对该分子及其家族的深入研究，人们发现RELMβ广泛参与 机体各种生理及病理过程的调控，且能够作为疾病发生的始动因子介导多条信号转导通路，参与 疾病的发生与发展，并有望成为相关疾病治疗中的新靶点。本文就近年来关于RELMβ的研究现状 作一综述。
关键词：
抵抗素样分子β
哮喘
肺动脉高压
特发性肺纤维化
动脉粥样硬化
结肠癌
Recent progress of RELMβ
CorrespondingAuthor: DAI Aiguo Email: daiaiguo2003@163.com
DOI: 10.3978/j.issn.2095-6959.2014.06.037
Abstract
Resistin-like molecule β (RELMβ), originally identified as an intestinal secretory protein, played an important role in proliferation and local immunity of intestine. With the in-depth study of RELMβ and its related family, people found it extensively participate in various regulation of physiological and pathological process of our body, otherwise it mediated a variety of signal transduction pathway as a disease initial factor. Therefore RELMβ involved in the occurrence and development of disease and be a new target of related disease therapy. This review summarized the research progress of RELMβ in recent year.