β-位点淀粉样前体蛋白剪切酶-1在阿尔茨海默病中的表达、作用及其抑制剂
| 作者: |
1艾卫敏,
2汤姆,
2邓小华
1 湘潭医卫职业技术学院基础医学课部，湖南 湘潭 411104 2 中南大学基础医学院人体解剖学与神经生物学系，长沙 410013 |
| 通讯: |
艾卫敏
Email: 357053938@qq.com |
| DOI: | 10.3978/j.issn.2095-6959.2020.07.031 |
| 基金: | 湖南省教育厅课题(15C1359)；湖南省自然科学基金科教联合基金(2019JJ70043)；中南大学研究生自由探索项目(2019zzts726)；中南大学本科教育教学改革研究项目(2019jy135)。 |
摘要
阿尔茨海默病(Alzheimer’s disease，AD)是引起老年性痴呆的常见神经退行性疾病，主要临床表现为学习记忆功能减退、认知功能障碍，最终导致患者死亡。β-淀粉样蛋白(beta-amyloid protein，Aβ)是目前公认的AD发病的中心环节，由淀粉样前体蛋白(amyloid precursor protein，APP)经β-位点APP剪切酶-1(β-site APP cleavage enzyme-1，BACE-1)和γ-分泌酶降解生成，BACE-1介导了APP的第1次剪切，是Aβ产生的关键酶和限速酶，故BACE-1的活性决定其剪切产物Aβ的产生。
关键词：
阿尔茨海默病；β淀粉样蛋白；淀粉样前体蛋白；β-位点APP剪切酶-1
Expression and role of β-site amyloid precursor protein cleavage enzyme-1 in Alzheimer’s disease and its inhibitor
CorrespondingAuthor: AI Weimin Email: 357053938@qq.com
DOI: 10.3978/j.issn.2095-6959.2020.07.031
Foundation: This work was supported by the Fund Project of Hunan Province Education Office (15C1359), Science and Education Union Fund of Hunan Province Natural Science Foundation (2019JJ70043), Graduate Student Free Exploration Program of Central South University (2019zzts726), and the Undergraduate Educational Reform Research Project of Central South University (2019jy135), China.
Abstract
Alzheimer’s disease (AD) is a common neurodegenerative disease leading to dementia. Its main clinical manifestations are severe memory loss as well as cognitive and behavioral impairments, which eventually leads to death. Beta-amyloid protein (Aβ) is identified as a critical factor involved in the pathogenesis of AD. It is derived from amyloid precursor protein (APP) through the action of beta-site APP cleavage enzyme-1 (BACE-1) and γ-secretase. BACE-1 is beta-secretase 1. It mediates the first cut of APP and is the key and speed-limiting enzyme during the process of Aβ generation.
Keywords：
Alzheimer’s disease; β-amyloid protein; amyloid precursor protein; β-site APP cleavage enzyme-1