文章摘要

p16,E6/E7蛋白与宫颈癌及癌前病变相关性的研究进展

作者: 1曹 洁琼, 1王 晓宇, 2赵 烨
1 山西医科大学第一临床医学院,太原 030000
2 山西医科大学第一医院妇科,太原 030000
通讯: 赵 烨 Email: 643818223@qq.com
DOI: 10.3978/j.issn.2095-6959.2020.02.030

摘要

宫颈癌是女性最常见的、发病率较高、但完全可以通过筛查早期发现并进行有效防治的恶性肿瘤。在宫颈病变中,高危型HPV病毒的持续感染是导致其发生发展的明确病因,近年来,p16,HPV E6/E7蛋白在明确宫颈病变的发病机制、诊断、临床分流等方面的作用备受关注。
关键词: 宫颈病变;p16;HPV E6/E7;免疫组织化学分析

Research progress in correlation between p16, E6/E7 proteins and cervical cancer and precancerous lesions

Authors: 1CAO Jieqiong, 1WANG Xiaoyu, 2ZHAO Ye
1 First Clinical Medical College, First Hospital, Shanxi Medical University, Taiyuan 030000, China
2 Department of Gynecology, First Hospital, Shanxi Medical University, Taiyuan 030000, China

CorrespondingAuthor:ZHAO Ye Email: 643818223@qq.com

Abstract

Cervical cancer is the most common malignant tumor in women with high incidence, but can be detected early and effectively prevented by screening. In cervical lesions, the persistent infection of high-risk HPV virus is a clear cause of its development. In recent years, the role of P16 and HPV E6/E7 proteins in the pathogenesis, diagnosis and clinical shunt of cervical lesions has attracted much attention.
Keywords: cervical lesions; p16; HPV E6/E7; immunohistochemical analysis