文章摘要

急性肺损伤治疗措施的研究进展

作者: 1,2陈 艳, 1董 良, 1朱 昭琼
1 遵义医科大学附属医院麻醉科,贵州 遵义 563000
2 遵义医科大学研究生院,贵州 遵义 563000
通讯: 朱 昭琼 Email: zhuzhaoqiong@163.com
DOI: 10.3978/j.issn.2095-6959.2020.01.027
基金: 国家自然科学基金(81760019);贵州省中医药管理局课题(QZYY-2018-017)。

摘要

急性肺损伤(acute lung injury,ALI)及其严重形式急性呼吸窘迫综合征(acute respiratory distress syndrome,ARDS)是临床常见的急危重症,此类患者住院时间长、病死率高,其标志性病理特征为肺部炎症和肺组织结构破坏,主要临床表现为低氧合和低肺顺应性。ALI的发病机制并不是很明确,目前已知氧化应激及炎症反应失控是其发生发展的重要机制。临床上ALI常用治疗手段包括药物和机械通气等综合疗法,但其病死率仍居高不下。新兴的治疗方式如干细胞、分子靶向疗法等已取得一定研究成果,有望成为ALI潜在的可靠治疗方法。
关键词: 急性肺损伤;炎症;机械通气;治疗措施

Advances in the treatment of acute lung injury

Authors: 1,2CHEN Yan, 1DONG Liang, 1ZHU Zhaoqiong
1 Department of Anesthesiology, Affiliated Hospital of Zunyi Medical University, Zunyi Guizhou 56300, China
2 Department of Anesthesiology, Zunyi Medical University, Zunyi Guizhou 56300, China

CorrespondingAuthor:ZHU Zhaoqiong Email: zhuzhaoqiong@163.com

Foundation: This work was supported by National Natural Science Foundation (81760019) and Traditional Chinese medicine Administration of Guizhou (QZYY-2018-017), China.

Abstract

Acute lung injury (ALI) and its severe form of acute respiratory distress syndrome (ARDS) are common clinical acute and severe complications. Such patients mainly characterized by pulmonary inflammation and destruction of lung tissue structure. Clinically, ALI/ARDS patients is manifested by hypoxemia and decrease in lung compliance, which increase their hospital day and mortality rate, however, the pathogenesis of ALI is not very clear. Oxidative stress and inflammatory damage are proved to be important mechanisms. Even though drugs and mechanical ventilation therapy are effect to ALI patients, the mortality rate of ALI patients remains high. Emerging treatments such as stem cells and molecular targeted therapy have made some progress and are expected to become potential therapy for ALI.
Keywords: acute lung injury; inflammation; mechanical ventilation; therapeutic method