急性白血病患者应用含重组人粒细胞刺激因子的化疗方案致严重不良反应1例并文献复习
| 作者: |
1王丽莉,
2齐林,
3王亚丽,
4吴娜,
3王凤云,
3成志勇,
5王素云
1 定州市人民医院急诊科，河北 定州 073000 2 承德医学院研究生院，河北 承德 067000 3 保定市第一医院血液内科，河北 保定 071000 4 定州市人民医院血液内科，河北 定州 073000 5 深圳市龙华区中心医院血液内科，广东 深圳 511000 |
| 通讯: |
王素云
Email: suyunwcn@163.com |
| DOI: | 10.3978/j.issn.2095-6959.2019.10.038 |
摘要
重组人粒细胞刺激因子(recombinant human granulocyte colony-stimulating factor，rhG-CSF)能够促进髓系造血干细胞生成并分化为成熟中性粒细胞，可明显缩短骨髓抑制期，减少感染风险。其不良反应少见，但部分患者可能出现严重过敏反应，甚至低血压休克，过敏反应产生的机制目前并不完全清楚。保定市第一医院收治了1例对G-CSF出现严重不良反应，但仍需继续应用的白血病患者，经过一系列对症处理后患者病情稳定，最终达到骨髓部分缓解。
关键词：
重组人粒细胞刺激因子；不良反应；白血病；化疗
Serious adverse effects caused by chemotherapy with recombinant human granulocyte stimulating factor in patient with acute leukemia: A case report and literature review
CorrespondingAuthor: WANG Suyun Email: suyunwcn@163.com
DOI: 10.3978/j.issn.2095-6959.2019.10.038
Abstract
Recombinant human granulocyte colony-stimulating factor (rhG-CSF) can promote the generation and differentiation of myeloid hematopoietic stem cells into mature neutrophils, significantly shorten duration of bone marrow suppression and reduce the risk of infection. Its adverse reactions are rare, but some patients may have serious allergic reactions, even hypotensive shock. The mechanism of anaphylaxis is not completely clear at present. Baoding First Hospital admitted a patient with leukemia who had serious adverse reactions to G-CSF, but still needed to continue to use it. After a series of symptomatic treatment, the patient's condition was stable, and eventually achieved partial remission of bone marrow.
Keywords：
recombinant human granulocyte colony-stimulating factor; adverse reaction; leukemia; chemotherapy