1 广州市红十字会医院消化内科，广州 510220
目的：探讨中药联合护肝功法对慢性乙型肝炎后肝纤维化患者的治疗效果。方法：将符合入选要求的113名患者通过随机数字表法分为观察组(57名)和对照组(56名)，两组均常规应用西药+中药进行治疗，观察组在此基础上应用护肝功法进行干预，治疗时间为3个月。比较两组治疗前后的肝功能、肝纤维化指标和生命质量情况。结果：在肝功能方面，治疗后两组的TBIL，ALT和AST均明显改善，且观察组明显低于对照组，差异具有统计学意义(P<0.05)；在肝纤维化指标方面，两组在治疗后的血清透明质酸(hyaluronic acid，HA)、层黏蛋白(laminin，LN)、IV型胶原(type IV collagen，IV-C)和III型前胶原(type III procollagen，PCIII)均明显改善，且观察组明显低于对照组，差异具有统计学意义(P<0.05)；在生命质量方面，两组在治疗后的简明健康自评问卷(Short Form 36 Health survey Questionnaire，SF-36)各维度得分均明显高于治疗前，且观察组明显高于对照组，差异具有统计学意义(P<0.05)。结论：中药联合护肝功锻炼能有效改善慢性乙型肝炎后的肝纤维化，提升生命质量。
Chinese herbal medicine combined with liver protection therapy in patients with liver fibrosis after chronic hepatitis B
This work was supported by the Construction of Strong Province of Traditional Chinese Medicine in 2012 to Support Scientific Research Projects, China [Guangdong traditional Chinese medicine (2012) No. 23].
Objective: To investigate the effect of Chinese herbal medicine combined with liver protection therapy on liver fibrosis in patients with chronic hepatitis B. Methods: A total of 113 patients enrolled in the requirements were randomly divided into observation group (57 cases) and control group (56 cases), two groups were treated with routine application of Western medicine combined with traditional Chinese medicine treatment, the observation group based on the application of liver intervention method, treatment time was 3 months. The liver function, liver fibrosis index and quality of life were compared between the two groups before and after treatment. Results: In liver function, TBIL, ALT and AST of the two groups were significantly improved, and the observation group were significantly lower than the control group after intervention (P<0.05); serum hyaluronic acid (HA), laminin (LN), type IV collagen (IV-C) and type III procollagen (PCIII) were significantly improved in the two groups after intervention (P<0.05), and the observation group were significantly lower than the control group after intervention (P<0.05). In the quality of life, each dimension scores of Short Form 36 Health survey Questionnaire (SF-36) of the observation group was higher than that of the control group (P<0.05), and the observation group was higher than that of the control group after intervention (P<0.05). Conclusion: Chinese herbal medicine combined with liver strengthening exercise can effectively improve the liver function of patients with liver fibrosis after chronic hepatitis B, and improve the quality of life.
chronic hepatitis B; hepatic fibrosis; traditional Chinese medicine; liver protection therapy