文章摘要

磷脂酰肌醇3激酶/蛋白激酶B/雷帕霉素靶蛋白信号通路在肺部疾病中的研究进展

作者: 1杨春兰, 2戴爱国
1 南华大学附属省老年医院呼吸科/湖南省老年医学研究所呼吸疾病研究室，长沙 410016
2 湖南省长沙医学院呼吸系统疾病研究所，长沙 410219
通讯: 戴爱国 Email: daiaiguo2003@163.com
DOI: 10.3978/j.issn.2095-6959.2017.04.028
基金: 国家自然科学基金, 81270118 湖南省研究生创新性课题, CX2016B496

摘要

磷脂酰肌醇3激酶/蛋白激酶B/雷帕霉素靶蛋白(phosphatidylinositol-3-kinase/protein kinase B/mammalian target of rapamycin，PI3K/Akt/mTOR)是细胞内重要信号通路，在细胞生长、增殖、分化和蛋白合成等过程中起重要作用。肺癌、哮喘、肺动脉高压、肺纤维化、慢性阻塞性肺疾病(chronic pulmonary obstructive disease，COPD)等疾病是呼吸系统常见疾病，其病理机制涉及细胞增殖及凋亡等，与PI3K/Akt/mTOR信号通路关系密切。
关键词： 磷脂酰肌醇3激酶/蛋白激酶B/雷帕霉素靶蛋白信号通路 呼吸系统疾病 病理机制

Research progress of phosphatidylinositol-3-kinase/protein kinase B/mammalian target of rapamycin signal pathway in pulmonary diseases

Authors: 1YANG Chunlan, 2DAI Aiguo
1 Department of Respiratory, Hunan Geriatric Hospital Affiliated to University of South China/Hunan Geratic Respiratory Disease Institute, Changsha 410016
2 Respiratory Disease Institute, Changsha Medical University, Changsha 410219, China

CorrespondingAuthor: DAI Aiguo Email: daiaiguo2003@163.com

DOI: 10.3978/j.issn.2095-6959.2017.04.028

Abstract

Phosphatidylinositol-3-kinase/protein kinase B/mammalian target of rapamycin (PI3K/Akt/mTOR) signal pathway is an important intracellular signal pathway, playing pivotal role in cell growth, proliferation, differentiation, DNA synthesis. Pulmonary carcinoma, asthma, pulmonary artery hypertension, pulmonary fibrosis, chronic pulmonary obstructive disease (COPD) are common chronic respiratory diseases, and their patho-mechanisms involve cell proliferation and growth, which have intimate relationship with PI3K/Akt/mTOR.

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