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精氨酸加压素受体阻断剂改善小鼠脑卒中后脑水肿和血脑屏障破坏

  
@article{LCBL5647,
	author = {军 熊 和 春联 潘},
	title = {精氨酸加压素受体阻断剂改善小鼠脑卒中后脑水肿和血脑屏障破坏},
	journal = {临床与病理杂志},
	volume = {36},
	number = {1},
	year = {2016},
	keywords = {},
	abstract = {目的:探讨精氨酸加压素(arginine-vasopressin,AVP)受体阻滞剂盐酸考尼伐坦和托伐普坦是否可以减少小鼠卒中后脑水肿和血脑屏障(blood-brain barrier,BBB)破坏。方法:C57BL/6小鼠进行大脑中动脉阻塞后再灌注。盐酸考尼伐坦、托伐普坦或溶剂(vehicle)分别处理小鼠。再灌开始时静脉注射盐酸考尼伐坦48 h或口服托伐普坦。记录实验小鼠生理变量、神经功能缺损评分(neurological deficit score,NDS)和血、尿钠及渗透压。小鼠处死后评价脑水含量(brain water content,BWC)和伊万斯蓝(evans blue,EB)外渗。结果:盐酸考尼伐坦和托伐普坦均可引起血浆和尿液中钠含量变化。然而,仅盐酸考尼伐坦改变血浆和尿液渗透压。盐酸考尼伐坦改善NDS,降低同侧大脑半球BWC(vehicle:81.66±0.43% vs. 盐酸考尼伐坦:78.28±0.48%,P},
	url = {https://lcbl.amegroups.com/article/view/5647}
}