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circ_0010729靶向miR-654-3p介导高糖诱导的肾小球系膜细胞凋亡及炎症反应

   
@article{LCBL50629,
	author = {颖 陈 和 爽 徐 和 炟 王},
	title = {circ_0010729靶向miR-654-3p介导高糖诱导的肾小球系膜细胞凋亡及炎症反应},
	journal = {临床与病理杂志},
	volume = {42},
	number = {10},
	year = {2022},
	keywords = {},
	abstract = {目的：探讨circ_0010729对高糖诱导的肾小球系膜细胞损伤的影响。方法：将人肾小球系膜细胞HMCL分为对照组、高糖(high glucose，HG)组、HG+si-NC组、HG+si-circ_0010729组、HG+miR-NC组、HG+miR-654-3p组、HG+si-circ_0010729+anti-miR-NC组、HG+si-circ_0010729+anti-miR-654-3p组。Real-time PCR检测circ_0010729和miR-654-3p的表达水平；流式细胞术检测细胞凋亡；ELISA检测白细胞介素-6(interleukin-6，IL-6)、肿瘤坏死因子-α(tumor necrosis factor-α，TNF-α)水平；双荧光素酶报告实验验证circ_0010729和miR-654-3p的靶向关系。结果：与对照组比较，HG组circ_0010729表达水平升高，miR-654-3p表达水平降低，细胞凋亡率升高，TNF-α、IL-6水平升高(P},
	url = {https://lcbl.amegroups.com/article/view/50629}
}