目的：观察家庭长期无创通气(noninvasive positive pressure ventilation，NIPPV)治疗对重度慢性阻塞性 肺疾病(chronic obstructive pulmonary disease，COPD)稳定期的治疗效果。方法：收集2009年8月至2012 年8月本院呼吸科确诊为重度COPD，使用家庭NIPPV 12个月以上的11例患者，通过自身对照方法， 将患者治疗前后的肺功能、血气分析、生活质量、住院次数、6分钟步行实验结果进行对比观察。 结果：9例完成疗程的患者治疗前后血气分析及6分钟步行实验结果差异均有统计学意义(P<0.05)，患 者生活质量明显提高，住院次数明显减少。结论：家庭长期使用NIPPV，能改善重度COPD患者的血 气，患者生活质量提高，住院次数减少，是目前最有效降低COPD患者病死率的方法。
Long term domiciliary noninvasive positive pressure ventilation in patients with severe stable chronic obstructive pulmonary disease
Objective: To observe the effect of long term noninvasive positive pressure ventilation in patients with severe stable chronic obstructive pulmonary disease. Methods: Collected 11 patients with severe COPD who all treated with long-term NIPPV more than 12 months from 2009 August to 2012 August in our hospital department of respiration. The lung function, blood gas analysis, quality of life, the hospital admissions and the result of 6 min walk test were observed and compared with self-control method. Results: There was significant difference between the beginning and termination of the treatment in 9 patients having finished the treatment (P<0.05). The evaluation of quality of life, and the hospital admissions had significant changes before and after NIPPV used. Conclusion: Long term domiciliary NIPPV can improve the blood gas analysis of sever stable COPD patients. The hospital admissions were decreased significantly and quality of life improved. NIPPV is an effective method for COPD.