论著 Original Article

外周血白介素-35与肿瘤相关性的Meta分析

Published at: 2015年第35卷第6期

陈相军 1 , 吴青霞 2 , 陈敏 1 , 刘芳 1 , 李念 1
1 四川大学华西医院,成都 610041
2 四川大学公共管理学院,成都 610021
通讯作者 相军 陈 Email: drchenxj@scu.edu.cn
DOI: 10.3978/j.issn.2095-6959.10.3978/j.issn.2095-6959.2015.06.040
基金:

摘要

目的:评价外周血白介素–35水平与肿瘤危险的相关性。方法:计算机检索PubMed、MEDLINE、EMBASE、CNKI和万方等数据库,检索2015年1月15日以前公开发表的文献。采用RevMan5.2.2分析软件对其进行分析和评价。结果:通过检索,最终纳入5篇研究。Meta分析结果显示外周血白介素–35浓度在癌症患者和正常组之间无明显差别(MD =41.91;95% CI,−6.33~90.15;P=0.09)。亚组分析也表明IL-35在白血病或其他癌症与正常对照组之间并无显著差异(MD =23.73;95% CI,−15.63~63.09;P=0.24);(MD =60.00;95% CI,−57.86~177.87;P=0.32)。性别研究分析表明,男性癌症患者中的外周血IL-35浓度与女性患者之间并无显著差异(MD =−3.25,95% CI,−8.39~1.88;P=0.21)。外周血IL-35在癌症淋巴结转移和无淋巴结转移病人中存在显著差异(MD =−23.18,95% CI,−37.93~−8.43, P=0.002)。结论:外周血IL-35浓度在癌症病人中并无显著相关性,但是可以作为癌症淋巴结转移有无的一个预测指标。


Meta-analysis of association of circulation interleukin-35 with cancer

Abstract

Objective: To review systematically the association of circulation interleukin 35 (IL-35) with cancer risk. Methods: The databases of PubMed, MEDLINE, EMBASE, China National Knowledge Infrastructure (CNKI) and WangFang up to Jan 15, 2015 were searched for relevant articles. Meta-analysis was conducted using RevMan 5.2.2 software. Results: Total five studies were finally included into this meta-analysis. The results of meta-analysis shown that no association of circulation IL-35 level between cancer patients and controls (MD =41.91; 95% CI, −6.33~90.15; P=0.09). Subgroups analysis also shown that there were no significantly differences on IL-35 level between leukemia or other cancers and controls (MD =23.73, 95% CI, −15.63~63.09; P=0.24; MD =60.00, 95% CI, −57.86~177.87; P=0.32; respectively). Moreover, no associated to IL-35 between male and female patients (MD =−3.25, 95% CI, −8.39~1.88, P=0.21). However, there was a significantly difference on association between lymph node metastasis and no-lymph node metastasis (MD =−23.18, 95% CI, −37.93~−8.43, P=0.002). Conclusion: No association between cancer patients and controls, but it can be as a predictor for lymph node metastasis patients.


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引用

引用本文: 相军 陈, 青霞 吴, 敏 陈, 芳 刘, 念 李. 外周血白介素-35与肿瘤相关性的Meta分析[J]. 临床与病理杂志, 2015, 35(6): 1075-1079.
Cite this article as: CHEN Xiangjun, WU Qingxia, CHEN Min, LIU Fang, LI Nian . Meta-analysis of association of circulation interleukin-35 with cancer[J]. Journal of Clinical and Pathological Research, 2015, 35(6): 1075-1079.