目的：探讨肺癌肉瘤(pulmonary carcinosarcoma，LCS)的临床病理学特点及诊断要点。方法：对1例 LCS进行临床资料、病理形态学及免疫组化观察，并结合文献对其诊断及鉴别诊断进行探讨。 结果：镜下见癌和肉瘤成分相互混杂，无过渡形式存在，癌的成分为中分化鳞状细胞癌，可以见 到癌细胞呈巢团状、片状排列，可以见到细胞间桥，偶尔可以见到角化珠，癌细胞异型性明显， 可见核分裂象；肉瘤成分为纤维肉瘤，瘤细胞以梭形细胞为主，异型性较大，核分裂象多见。 免疫组化显示鳞状细胞癌成分CK5/6、P63表达阳性，肉瘤成分vimentin表达阳性，符合LCS。 结论：掌握LCS病理特点，提高对LCS的认识，对避免误诊是至关重要的。
Clinicopathologic analyses of pulmonary carcinosarcoma and review of the literature
Objective: To explore the characteristics of clinicopathology and diagnostic criteria about pulmonary carcinosarcoma (LCS). Methods: The clinical data, histopathologic observation and immunohistochemical staining were studied in one case of lung carcinosarcoma, in order to explore its diagnosis and differential diagnosis combined with literatures. Results: Microscopic examination showed that the component of carcinoma and sarcoma was mixed each other without transitional forms. The component of carcinoma was moderately differentiated squamous cell carcinoma, and the tumor cells were nest clumps or flake. Intercellular bridges were seen with keratin pearl, occasionally. The tumor cells were pleomorphism obviously with visible nuclear fission. Conclusion: It is essential to grasp the pathological characteristics of lung carcinosarcoma to avoid misdiagnosis with raising awareness.