综述 Review

转录因子在上皮间质转化中分子机制研究进展

Published at: 2015年第35卷第3期

郭鹏 1 , 董栋栋 2 , 王进 1 , 许建发 1 , 冯和林 1
1 河北医科大学第四医院 骨科,石家庄 050000
2 河北医科大学第四医院 泌尿外科,石家庄 050000
通讯作者 和林 冯 Email: fenghelin0311@126.com
DOI: 10.3978/j.issn.2095-6959.10.3978/j.issn.2095-6959.2015.03.028
基金:
河北省自然基金面上项目 H2015206314

摘要

上皮细胞-间充质转化(epithelia-mesenchymal transition,EMT),是指上皮细胞通过特定程序转化为 具有间质表型细胞的生物学过程,目前研究证实这种表型的转化与转录因子密不可分。与其他转 录因子相比,转录因子SNAIL、TWIST、ZEB为促进EMT过程的主要转录因子,本文总结国内外 与EMT相关研究并对转录因子及其在EMT过程中的分子机制加以综述。


Recent progress of research on molecular mechanism of transcription factors in epithelial mesenchymal transition

Abstract

The transdifferentiation of epithelial cells into motile mesenchymal cells was known as epithelial-mesenchymal transition (EMT). This switch in cell behavior has been illustrated to be mediated and closely related by some key transcription factors, including SNAIL, zinc-finger E-box-binding (ZEB) and basic helix–loop–helix transcription factors (TWIST). This article reviewed the research of recent progress of transcription factors the related mechanism of EMT.


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引用

引用本文: 鹏 郭, 栋栋 董, 进 王, 建发 许, 和林 冯. 转录因子在上皮间质转化中分子机制研究进展[J]. 临床与病理杂志, 2015, 35(3): 479-483.
Cite this article as: GUO Peng, DONG Dongdong, WANG Jing, XU Jianfa, FENG Helin . Recent progress of research on molecular mechanism of transcription factors in epithelial mesenchymal transition[J]. Journal of Clinical and Pathological Research, 2015, 35(3): 479-483.