上皮细胞-间充质转化(epithelia-mesenchymal transition，EMT)，是指上皮细胞通过特定程序转化为 具有间质表型细胞的生物学过程，目前研究证实这种表型的转化与转录因子密不可分。与其他转 录因子相比，转录因子SNAIL、TWIST、ZEB为促进EMT过程的主要转录因子，本文总结国内外 与EMT相关研究并对转录因子及其在EMT过程中的分子机制加以综述。
Recent progress of research on molecular mechanism of transcription factors in epithelial mesenchymal transition
The transdifferentiation of epithelial cells into motile mesenchymal cells was known as epithelial-mesenchymal transition (EMT). This switch in cell behavior has been illustrated to be mediated and closely related by some key transcription factors, including SNAIL, zinc-finger E-box-binding (ZEB) and basic helix–loop–helix transcription factors (TWIST). This article reviewed the research of recent progress of transcription factors the related mechanism of EMT.