综述 Review

5-LOX代谢途径与牙周炎相关性的研究进展

Published at: 2015年第35卷第2期

罗华珍 1 , 和红兵 1
1 昆明医科大学附属口腔医院牙周病科,昆明 650031
通讯作者 红兵 和 Email: 1320058043@qq.com
DOI: 10.3978/j.issn.2095-6959.10.3978/j.issn.2095-6959.2015.02.028
基金:
云南省应用基础研究重点项目 40212093

摘要

花生四烯酸的代谢产物在炎症性骨破坏疾病的病理过程中发挥着重要的作用,其主要病理机制为 破骨细胞的形成和活化,近年来发现花生四烯酸经脂氧酶(1ipoxygenase,LOX)途径代谢的产物LTB4 在牙周炎患者龈沟液中的含量高于正常者,给予5-LOX抑制剂的炎症模型中破骨细胞的数量和骨破 坏的程度均低于对照组,因而探讨花生四烯酸经5-LOX途径代谢对牙周炎的影响及其机制将有利于 进一步阐明牙周炎的发病机理,为牙周炎的防治提出新的思路,本文就有关花生四烯酸脂氧酶代谢 途径与牙周炎关系的研究做一综述。


Recent advances on the correlation between 5-LOX pathway of arachidonic acid and periodontitis

Abstract

The metabolism of arachidonic acid plays a significant role in the pathological process of inflammatory bone destruction disease. The main pathomechanism is osteoclast formation and activation. In recent years, evidence suggests that the level of LTB4 metabolized by LOX enzymatic pathway is elevated in gingival crevicular fluid of patients with periodontitis compared with periodontal health. Giving inhibitor of 5-LOX to the inflammation model showed that the number of osteoclast and the degree of bone destruction are all below when compared with normal control. Therefore, discuss arachidonic acid metabolized by 5-LOX enzymatic pathway how to influence as well as mechanism on periodontitis will be conducive to expound pathogenesis of periodontitis. It proposes a new idea for the prevention and treatment of periodontitis. In this article the relationship between 5-LOX pathway of arachidonic acid and periodontitis will be reviewed.


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引用

引用本文: 华珍 罗, 红兵 和. 5-LOX代谢途径与牙周炎相关性的研究进展[J]. 临床与病理杂志, 2015, 35(2): 296-300.
Cite this article as: LUO Huazhen, HE Hongbing . Recent advances on the correlation between 5-LOX pathway of arachidonic acid and periodontitis [J]. Journal of Clinical and Pathological Research, 2015, 35(2): 296-300.