临床病例讨论 Case Analysis

粒细胞-巨噬细胞集落刺激因子治疗肺泡蛋白沉积症1例

Published at: 2017年第37卷第8期

韩晓晓 1 , 闫冰迪 1 , 杨俊玲 1 , 林苏杰 1 , 张辉 1
1 吉林大学第二医院呼吸内科,长春 130000
通讯作者 俊玲 杨 Email: junling@jlu.edu.cn
DOI: 10.3978/j.issn.2095-6959.2017.08.038
基金:

摘要

收集1例肺泡蛋白沉积症(pulmonary alveolar proteinosis,PAP)患者临床资料并相关文献复习。患者因气短4个月,加重1个月入院,行纤维支气管镜活检。经过碘酸雪夫(Periodic acid-Schiff,PAS)染色阳性明确诊断为PAP,在经2次全肺灌洗治疗,病情反复后给予皮下注射粒细胞–巨噬细胞集落刺激因子,病情得到改善,提示对特发性PAP患者皮下注射粒细胞–巨噬细胞集落刺激因子是一种可行的治疗方法。


One case of granulocyte-macrophage colony stimulating factor therapy for alveolar protein deposition

Abstract

The clinical data of 1 patient with pulmonary alveolar proteinosis were collected and the related literatures were reviewed. Patient was hospitalized with air shortness of time for 4 months, 1-month exacerbation, and did transbronchial biopsy. After Periodic acid-Schiff staining positive, the patient was diagnosed as pulmonary alveolar protein deposition. After the whole lung lavage for 2 times, the patient was given subcutaneous injection of granulocyte-macrophage colony stimulating factor after the disease repeating; the condition of the state improved as well. It suggests that subcutaneous injection of granulocyte-macrophage colony stimulating factor in idiopathic PAP patients is a viable method.


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引用

引用本文: 晓晓 韩, 冰迪 闫, 俊玲 杨, 苏杰 林, 辉 张. 粒细胞-巨噬细胞集落刺激因子治疗肺泡蛋白沉积症1例[J]. 临床与病理杂志, 2017, 37(8): 1764-1768.
Cite this article as: HAN Xiaoxiao, YAN Bingdi, YANG Junling, LIN Sujie, ZHANG Hui . One case of granulocyte-macrophage colony stimulating factor therapy for alveolar protein deposition[J]. Journal of Clinical and Pathological Research, 2017, 37(8): 1764-1768.