论著 Original Article

子宫内膜样腺癌中Stathmin和Ki-67的表达及意义

Published at: 2017年第37卷第7期

熊中堂 1 , 江庆萍 1 , 刘少颜 1 , 丘福满 2
1 广州医科大学附属第三医院病理科,广州 510150
2 广州医科大学公共卫生学院化学致癌研究所,广州 511436
通讯作者 福满 丘 Email: fumanqiu@gzhmu.edu.cn
DOI: 10.3978/j.issn.2095-6959.2017.07.006
基金:
国家自然科学基金 81602289
广州市科技计划项目 201707010123

摘要

目的:研究Stathmin和Ki-67在子宫内膜样腺癌和正常子宫内膜中的表达差异,探讨Stathmin和Ki-67在子宫内膜样腺癌发生发展过程中的意义。方法:采用免疫组织化学法检测99例子宫内膜样腺癌及67例正常子宫内膜中Stathmin 和Ki-67的表达情况。结果:子宫内膜样腺癌中Stathmin和Ki-67表达率分别为75.8%,70.7%,显著高于正常子宫内膜中的9.0%,4.5%,差异有统计学意义(P<0.05);Stathmin和Ki-67表达与子宫内膜样腺癌组织学分级相关(P<0.05),与患者年龄、临床分期、浸润深度、淋巴结转移及脉管侵犯无关(P>0.05);Stathmin表达和Ki-67表达呈正相关(r=0.672,P<0.05)。结论:子宫内膜样腺癌中Stathmin和Ki-67高表达可能共同参与子宫内膜样腺癌发生和分化;Stathmin和Ki-67表达呈正相关,提示Stathmin高表达可能与子宫内膜样腺癌高增殖性相关。


Expression and significance of stathmin and Ki-67 in endometrioid adenocarcinoma

Abstract

Objective: To investigate the expression of Stathmin and Ki-67 in endometrioid adenocarcinoma and its significance. Methods: Immunohistochemical staining for Stathmin and Ki-67 was performed in 99 cases of endometrioid adenocarcinoma and 67 cases of normal endometrium. Results: The expression rates of Stathmin and Ki-67 in endometrioid adenocarcinoma were 75.8% and 70.7%, respectively. The high expression rates of Stathmin and Ki-67 in normal endometrioma were 9.0% and 4.5%, respectively. The difference between endometrioid adenocarcinoma and normal endometrioma was significant (P<0.05). The expression of Stathmin and Ki-67 in endometrioid adenocarcinoma was related with its histology grading (P<0.05), but was not related with patients' age, clinical stage, invasion depth, lymph node metastasis and vascular invasion (P>0.05). The expression of Stathmin and Ki-67 were significantly positively correlated (r=0.672, P<0.05). Conclusion: The occurrence and differentiation of endometrial adenocarcinoma may be ralated with the high expressions of Stathmin and Ki-67. The expression of Stathmin and Ki-67 were significantly positively correlated indicated that the high expression of Stathmin may be associated with higher proliferation of the endometrial adenocarcinoma.


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引用

引用本文: 中堂 熊, 庆萍 江, 少颜 刘, 福满 丘. 子宫内膜样腺癌中Stathmin和Ki-67的表达及意义[J]. 临床与病理杂志, 2017, 37(7): 1361-1366.
Cite this article as: XIONG Zhongtang, JIANG Qingping, LIU Shaoyan, QIU Fuman . Expression and significance of stathmin and Ki-67 in endometrioid adenocarcinoma[J]. Journal of Clinical and Pathological Research, 2017, 37(7): 1361-1366.