目的：探讨综合护理方法在阿尔茨海默病患者奥拉西坦治疗中的应用效果。方法：选取2013年 5月至2017年1月哈尔滨医科大学附属第二医院收治的86例阿尔茨海默病患者作为研究对象，按入院时间将其分为对照组(2013年5月至2015年5月)和干预组(2015年6月至2017年1月)，每组43例。所有患者予以阿尔茨海默病常规基础联合奥拉西坦等药物对症治疗，对照组予以常规临床护理，干预组患者予以综合护理模式干预，两组均干预两周。干预结束后比较两组神经功能、记忆功能、生活质量和抑郁情况，以及患者/患者家属对护理的满意度。结果：干预后两组美国国立卫生研究院卒中神经功能缺损评分(National Institute of Health stroke scale，NIHSS)较干预前明显降低，而韦氏记忆测试修订版(Wechsler Memory Scale-Revised，WMS-R)评分均较干预前明显升高，差异有统计学意义(P<0.05)，但两组干预后比较，差异无统计学意义(P>0.05)；两组干预后其日常生活自理能力表(Activity of Daily Living Scale，ADL)和汉密尔顿抑郁量表(Hamilton Anxiety Scale，HAMA)评分均较干预前降低，且干预组降低程度明显大于对照组，差异有统计学意义(P<0.05)；干预组护理总满意度与对照组比较差异有统计学意义(97.67% vs 83.72%，P<0.05)。结论：综合性护理可明显提高予以奥拉西坦治疗的阿尔茨海默病患者的生活质量，并降低其抑郁程度，同时更易于被患者及家属所接受，可作为临床上阿尔茨海默病患者的优选护理模式。
Effect of comprehensive nursing in the treatment of elderly patients with dementia by oxiracetam for improving the neurological function and memory function
Objective: To investigate the effect of comprehensive nursing in the treatment of Alzheimer’s disease by oxiracetam for improving the neurological function and memory function. Methods: Eighty-six Alzheimer’s disease patients with dementia from May 2013 to January 2017 in Second Affiliated Hospital of Harbin Medical University were selected as the research object. According to the nursing method, the patients were divided into a control group (May 2013 to May 2015) and an intervention group (June 2015 to January 2017) according to the time of admission with 43 cases in each group. All patients were given with conventional symptomatic treatment combined with oxiracetam drugs. The control group of patients were given with routine clinical care and the intervention group of patients with comprehensive nursing mode with 2-week intervention. The neurological function, memory function, quality of life and depression after the intervention, and the patients or family satisfaction with nursing were compared between two groups. Results: After the intervention, the National Institute of Health stroke scale (NIHSS) score of the two groups were significantly decreased compared with before intervention, the scores of Wechsler Memory Scale-Revised (WMS-R) increased significantly (P<0.05), but those in two groups after the intervention had no significant difference (P>0.05); after the intervention, the Activity of Daily Living Scale (ADL) and Hamilton Anxiety Scale (HAMA) scores were lower than that in before intervention in two groups. The decreased degree of intervention group were significantly higher than that of control group, the difference was statistically significant (P<0.05); the nursing satisfaction between the intervention group and the control group were significantly different (97.67% vs 83.72%, P<0.05). Conclusion: Comprehensive nursing can significantly improve the quality of life and reduce the degree of depression in the treatment of Alzheimer's disease patients with dementia by oxiracetam, and easier to be accepted by the patients and their families, which can be used as the preferred mode of clinical nursing on patients with dementia.