Effect of LDL-c/HDL-c in formation of carotid artery plaque in female patients with type 2 diabetes mellitus
Objective: To evaluate the significance of LDL-c/HDL-c (L/H) in formation of carotid artery plaque in female patients with type 2 diabetes mellitus. Methods: A total of 210 female patients with type 2 diabetes mellitus were divided into two groups: the experimental group consists of 100 cases who had carotid artery plaque and the control group included 110 cases without carotid artery plaque according to results of color Doppler ultrasound in carotid artery. The general clinical data and risk factors of carotid artery plaque were collected and compared; The clinic advantages of LDL-c/HDL-c were evaluated by single factor analysis, logistic regression analysis, receiving the ROC curves, and so on. Results: There were statistical differences between the two groups in age, the course of disease, the systolic pressure, HbA1c, UA, LDL-c, HDL-c and L/H (P<0.05). There was no significant difference in their BMI, TC, TG and diastolic blood pressure (P>0.05). With the method of rejecting confounding factors and with the help of logistic regression analysis, OR values of ages, HbA1c, UA and LDL-c/HDL-c were 1.128, 1.469, 1.005 and 1.952 respectively, which indicated they were risk factors in developing carotid artery plaque. The area under the ROC curve of LDL-c/HDL-c was 0.689 and that of LDL-c was 0.571, showing that LDL-c/HDL-c was better than LDL-c as an evaluation parameter. Conclusion: More comprehensiveness, accuracy and value can be achieved when applying L/H to evaluating diabetic angiopathy.