综述 Review

Hippo信号通路与肾病

Published at: 2017年第37卷第7期

郑志煌 1 , 张志刚 2 , 吴慧娟 2 , 刘军 1
1 上海交通大学附属第一人民医院肾内科,上海 200080
2 复旦大学基础医学院病理系,上海 200032
通讯作者 慧娟 吴 Email: hjwu@shmu.edu.cn
DOI: 10.3978/j.issn.2095-6959.2017.07.034
基金:
上海市科委科创项目 15140902900
上海市自然科学基金 15ZR1433500

摘要

Hippo信号通路是近年来备受关注的一条调节器官生长和组织大小的重要信号通路,其已被证实在肿瘤的发生、发展中发挥重要作用。目前Hippo信号通路与肾病的相关性研究仍处于起步阶段。在急性肾损伤(acute renal injury,AKI)方面,Hippo信号通路可能参与小管上皮细胞的凋亡、上皮–间质转化(epithelial-mesenchymal transition,EMT)以及AKI进展至慢性肾脏病(chronic kidney disease,CKD)等多个环节。此外,Hippo信号通路还参与多种慢性肾脏病,包括局灶节段性肾小球硬化症、糖尿病肾病、多囊肾等的发生和疾病进展。


Hippo signaling pathway in kidney diseases

Abstract

Hippo signaling pathway is an important signaling pathway that regulates organ growth and tissue size, which has been received much concern recently and shown to play an important role in the development and progression of tumors. For now, researches about the relationship of Hippo signaling pathway and kidney diseases are still at the initial stage. In acute renal injury, Hippo signaling pathway may be involved in the apoptosis of tubule epithelial cells, epithelial-mesenchymal transition (EMT) and acute renal injury (AKI) progress to chronic kidney disease (CKD) and other processes. In addition, Hippo signaling pathway is also involved in the development and progression of a variety of chronic kidney diseases, including focal segmental glomerulosclerosis, diabetic nephropathy, polycystic kidney disease. Therefore, this review will briefly summarize the researches progress about Hippo signaling pathway in the field of kidney diseases, so as to provide new insights and strategies for the prevention and treatment of kidney diseases.


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引用

引用本文: 志煌 郑, 志刚 张, 慧娟 吴, 军 刘. Hippo信号通路与肾病[J]. 临床与病理杂志, 2017, 37(7): 1518-1523.
Cite this article as: ZHENG Zhihuang, ZHANG Zhigang, WU Huijuan, LIU Jun . Hippo signaling pathway in kidney diseases[J]. Journal of Clinical and Pathological Research, 2017, 37(7): 1518-1523.