Research progress of serum low chlorine in various diseases
Chlorine (Cl–) is the main cell anion in the body, accompanied by sodium (Na+), mainly from dietary sources. Current studies have shown that changes in chloride ion concentration can be independent risk factors for multiple diseases. In particular, serum hypoxia has become an independent risk factor for cardiovascular disease, severe postoperative patients, and prognostic analysis of severe disease. Not only that, the extracellular chloride environment caused by intracellular chloride ion concentration is also reduced, leading to intracellular activation of a variety of kinases, ion channels and transporter activation, thereby enhancing the cell inflammatory response to the final formation of pathological damage.