综述 Review

血清低氯在多种疾病中的研究进展

Published at: 2017年第37卷第8期

李玉洁 1 , 李洪春 1,2 , 马萍 1,2 , 黄琳燕 1
1 徐州医科大学医学技术学院,江苏 徐州 221004
2 徐州医科大学附属医院检验科,江苏 徐州 221002
通讯作者 琳燕 黄 Email: huanglyl985@163.com
DOI: 10.3978/j.issn.2095-6959.2017.08.028
基金:
江苏省科技厅青年项目 BK20140228
国家自然科学基金 81402918

摘要

氯离子(Cl–)是身体中主要的细胞外阴离子,伴随着钠离子(Na+),主要从饮食来源。目前研究表明:Cl−浓度的改变可以成为多种疾病的独立风险因素。尤其是血清低氯已然成为心血管疾病(cardiovascular diseases,CVD)、严重术后患者、重症疾病的预后分析的独立风险因素。不仅如此,细胞外低氯环境造成胞内Cl−浓度也降低,导致胞内多种激酶活化,离子通道和转运蛋白激活,从而增强细胞的炎症反应最终形成病理损伤。


Research progress of serum low chlorine in various diseases

Abstract

Chlorine (Cl–) is the main cell anion in the body, accompanied by sodium (Na+), mainly from dietary sources. Current studies have shown that changes in chloride ion concentration can be independent risk factors for multiple diseases. In particular, serum hypoxia has become an independent risk factor for cardiovascular disease, severe postoperative patients, and prognostic analysis of severe disease. Not only that, the extracellular chloride environment caused by intracellular chloride ion concentration is also reduced, leading to intracellular activation of a variety of kinases, ion channels and transporter activation, thereby enhancing the cell inflammatory response to the final formation of pathological damage.


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引用

引用本文: 玉洁 李, 洪春 李, 萍 马, 琳燕 黄. 血清低氯在多种疾病中的研究进展[J]. 临床与病理杂志, 2017, 37(8): 1710-1714.
Cite this article as: LI Yujie, LI Hongchun, MA Ping, HUANG Linyan . Research progress of serum low chlorine in various diseases[J]. Journal of Clinical and Pathological Research, 2017, 37(8): 1710-1714.