Molecular features of pulmonary mucoepidermoid carcinoma
Objective: To investigate the molecular characteristics of pulmonary mucoepidermoid carcinoma (PMEC). Methods: From July 2013 to December 2016, 13 PMEC patients received treatment. All the patients were diagnosed by pathology. We retrospectively reviewed the clinical data and genetic state. Results: EGFR mutation rate was 15.38% (2/13), and 2 cases were both L861Q point mutations, the relationship between EGFR gene status and gender (P=1.000), age (P=1.000), smoking (P=0.848) and stage (P=1.000) were no significant; the positive rate of MAML2 fusion gene was 45.45% (5/11). the relationship between MAML2 fusion gene status and gender (P=0.521), age (P=0.521), smoking (P=1.000) and stage(P=0.924) were all no significant. Conclusion: The most common form change of pulmonary mucoepidermoid carcinoma was EGFR gene L861Q point mutation, MALM2 fusion gene exist in the EGFR gene wild type patients.