论著 Original Article

胰岛素生长因子受体-2在肝细胞癌预后判断中的临床价值

Published at: 2017年第37卷第6期

丁晶晶 1 , 陈洁 2,3 , 刘欣艳 1
1 上海市普陀区中心医院老年科,上海 200062
2 湖北医药学院附属随州医院肿瘤科,湖北 随州 44130
3 南通大学医学院肿瘤学,江苏 南通 226001
通讯作者 欣艳 刘 Email: xyan020699@163.com
DOI: 10.3978/j.issn.2095-6959.2017.06.026
基金:

摘要

目的:探讨胰岛素生长因子受体-2(insulin-like growth factor-2 receptor,IGF-2R)在肝细胞癌(hepatocellular carcinoma,HCC)预后判断中的临床价值。方法:采用免疫组织化学染色(IHC)检测人类肝癌组织中IGF-2R的表达,并分析IGF-2R组织水平与HCC患者临床病理特征之间关系。结果:IHC结果显示IGF-2R主要在HCC细胞的胞质和胞膜中表达,与匹配的癌旁正常组织相比,IGF-2R蛋白水平在HCC组织中更高,差异有统计学意义(P<0.05),并且与肿瘤分化程度正相关(P=0.012)。单变量和多变量生存分析显示TNM分期(HR=9.87,95%CI 4.13~17.80,P=0.008)、门脉癌栓(HR=5.21,95%CI 1.38~10.76,P=0.023)和IGF-2R高表达(HR=2.30,95%CI 1.20~5.01,P=0.033)与HCC患者预后不良相关。结论:这些数据表明IGF-2R表达与HCC患者的总体存活负相关,是潜在的HCC新型分子靶标和预后标志物。


Clinical value of IGF-2R in prognosis of hepatocellular carcinoma

Abstract

Objective: To study the clinical value of insulin-like growth factor-2 receptor (IGF-2R) in the prognosis of hepatocellular carcinoma (HCC). Methods: We examined IGF-2R expression in human HCC tissues by immunohistochemical staining, and investigated the clinical correlation between IGF-2R tissue levels and the clinicopathological characteristics of HCC patients. Results: Immunohistochemistry results revealed that IGF-2R was mainly expressed in the cell membrane and plasma of HCC cells. IGF-2R protein levels were significantly higher in HCC tissues when compared with matched non-cancerous tissues, the difference was statistically significant (P<0.05), and associated with the degree of tumor differentiation (P=0.012). Univariate and multivariate survival analysis revealed that patients with high IGF-2R expression (HR =9.87, 95% CI 4.13–17.80, P=0.008) and advanced TNM stage (HR =5.21, 95% CI 1.38–10.76, P=0.023) and poor prognosis (HR =2.30, 95% CI 1.20–5.01, P=0.033). Conclusion: These data indicate that IGF-2R expression is associated with the overall survival of HCC patients, and may represent a novel molecular target and new prognostic biomarker for HCC.


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引用

引用本文: 晶晶 丁, 洁 陈, 欣艳 刘. 胰岛素生长因子受体-2在肝细胞癌预后判断中的临床价值[J]. 临床与病理杂志, 2017, 37(6): 1226-1230.
Cite this article as: DING Jingjing, CHEN Jie, LIU Xinyan . Clinical value of IGF-2R in prognosis of hepatocellular carcinoma[J]. Journal of Clinical and Pathological Research, 2017, 37(6): 1226-1230.