近年来，人们对结直肠癌(colorectal cancer，CRC)发病机制及分子分型的研究日渐深入。根据CRC基因突变负荷的不同可将其分为高突变型CRC和非高突变型CRC。高突变型CRC包括微卫星不稳定型(microsatellite instability，MSI)CRC和POLE基因突变型CRC，非高突变型CRC主要指染色体不稳定(chromosomal instability，CIN)型CRC。
Molecular mechanism and treatment strategy of advanced colorectal cancer
In recent years, the study of the pathogenesis and molecular subtypes of colorectal cancer is becoming more and more deeply. There are two subtypes of colorectal cancer (CRC) depending on the mutation load: hypermutated subtype and non-hypermutated subtype. The hypermutated CRC including microsatellite instable CRC and POLE mutated CRC. The non-hypermutated CRC mainly refers to chromosomally instable CRC.