综述 Review

促红细胞生成素肝细胞激酶受体与ephrin配体及其信号转导在肿瘤中的研究进展

Published at: 2017年第37卷第5期

殷灵瑜 1 , 赵耀 1 , 李洪春 2 , 马萍 2 , 李世宝 2
1 徐州医科大学医学技术学院,江苏 徐州 221000
2 徐州医科大学 附属医院检验科,江苏 徐州 221000
通讯作者 世宝 李 Email: sdjnshlb@163.com
DOI: 10.3978/j.issn.2095-6959.2017.05.029
基金:
江苏省自然科学基金 BK20160233

摘要

促红细胞生成素肝细胞激酶(erythropoietin producing hepatocyte kinase,Eph)受体及其膜结合配体ephrin是最大的受体酪氨酸激酶(receptor tyrosine kinases,RTKs)家族,其不仅调节生物体的多种生理功能,而且参与多种疾病的发生发展过程。近年来,已有越来越多的证据表明肿瘤的发生发展与Eph家族成员异常表达密切相关。


Research progress in erythropoietin producing hepatocyte kinase receptor and ephrin ligand as well as their signal transduction in cancer

Abstract

Erythropoietin producing hepatocyte kinase (Eph) receptors and membrane binding ephrin ligands are the largest family of receptor tyrosine kinase, which not only regulate a great deal of physiological functions in organisms, but also participate in the occurrence and development of a variety of diseases. In recent years, there is more and more evidence that tumor development and Eph family members are closely related to abnormal expression.


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引用

引用本文: 灵瑜 殷, 耀 赵, 洪春 李, 萍 马, 世宝 李. 促红细胞生成素肝细胞激酶受体与ephrin配体及其信号转导在肿瘤中的研究进展[J]. 临床与病理杂志, 2017, 37(5): 1039-1046.
Cite this article as: YIN Lingyu, ZHAO Yao, LI Hongchun, MA Ping, LI Shibao . Research progress in erythropoietin producing hepatocyte kinase receptor and ephrin ligand as well as their signal transduction in cancer [J]. Journal of Clinical and Pathological Research, 2017, 37(5): 1039-1046.