论著 Original Article

PRSS3-mRNA与长链非编码RNA-PRSS3P2在甲状腺乳头状癌组织中的表达及其临床意义

Published at: 2017年第37卷第4期

何冰 1,2 , 王继纲 2 , 李玉军 2
1 青岛大学基础医学院病理学教研室,山东 青岛 266003
2 青岛大学附属医院病理科,山东 青岛 266003
通讯作者 继纲 王 Email: qdwangjigang@hotmail.com
DOI: 10.3978/j.issn.2095-6959.2017.04.003
基金:
国家自然科学基金 81502272

摘要

目的:检测PRSS3-mRNA及lncRNA-PRSS3P2在甲状腺乳头状癌(papillary thyroid carcinoma,PTC)及癌旁甲状腺组织中的表达特点,探讨二者在PTC中表达的临床病理意义。方法:收集2016年7至10月本院55例PTC及癌旁甲状腺组织的新鲜手术标本,应用荧光实时定量PCR检测PRSS3-mRNA及lncRNA-PRSS3P2在PTC和癌旁组织中表达情况,并分析其与临床病理特征的相关性。结果:PRSS3-mRNA及lncRNA-PRSS3P2在PTC组织中表达均明显高于非肿瘤组织;PRSS3P2的表达与患者的年龄相关(P<0.05),而PRSS3与各种临床病理特征无明显相关性。结论:在PTC组织中,PRSS3-mRNA和lncRNA-PRSS3P2的表达均明显升高,这提示二者可能参与了PTC的发病过程;PRSS3-mRNA和lncRNA-PRSS3P2可以作为PTC的诊断标志物进行进一步研究。


Expression and clinical significance of PRSS3-mRNA and LncRNA-PRSS3P2 in papillary thyroid carcinoma

Abstract

Objective: To detect the expressions of PRSS3-mRNA and lncRNA-PRSS3P2 in PTCs and their corresponding normal thyroid tissues, and to explore the clinicopathologic significance of PRSS3 and PRSS3P2 in PTC. Methods: A total of 55 fresh tissues of PTC plus with their paired normal thyroid tissues resected between July 1 and October 31, 2016 were collected. The expressions of PRSS3-mRNA and lncRNA-PRSS3P2 were detected by real-time quantitative PCR. The relationship between expressions of PRSS3/PRSS3P2 and the clinicopathologic features were carefully analyzed. Results: The expression levels of PRSS3 and PRSS3P2 in PTC tissues were obviously higher than their non-tumor counterparts (P<0.05). PRSS3P2 was correlated with the age of patients (P<0.05); however, PRSS3 is not associated with the clinicopathologic features of PTC. Conclusion: The expressions of PRSS3-mRNA and lncRNA-PRSS3P2 were increased in PTC. The present findings indicate that PRSS3 and PRSS3P2 may participate the development of PTC. PRSS3-mRNA and lncRNA-PRSS3P2 can be served as two potential diagnostic markers for PTC.


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引用

引用本文: 冰 何, 继纲 王, 玉军 李. PRSS3-mRNA与长链非编码RNA-PRSS3P2在甲状腺乳头状癌组织中的表达及其临床意义[J]. 临床与病理杂志, 2017, 37(4): 667-672.
Cite this article as: HE Bing, WANG Jigang, LI Yujun . Expression and clinical significance of PRSS3-mRNA and LncRNA-PRSS3P2 in papillary thyroid carcinoma[J]. Journal of Clinical and Pathological Research, 2017, 37(4): 667-672.