论著 Original Article

2013—2015年金黄色葡萄球菌的临床分布及耐药性分析

Published at: 2016年第36卷第12期

汪玥 1 , 秦婷婷 1 , 纵帅 2 , 康海全 2 , 邓丽华 2 , 马萍 1,2 , 徐银海 2 , 顾兵 1,2
1 徐州医科大学医学技术学院,江苏 徐州 221004
2 徐州医科大学附属医院检验科,江苏 徐州 221002
通讯作者 银海 徐 Email: 1755789156@qq.com
DOI: 10.3978/j.issn.2095-6959.2016.12.020
基金:
国家自然科学基金 81471994

摘要

目的:分析徐州医科大学附属医院2013—2015年金黄色葡萄球菌的临床分布及耐药情况,为临床用药提供依据。方法:收集2013年1月1日至2015年12月31日各类标本检出的金黄色葡萄球菌,临床分离株药敏实验采用标准纸片扩散(K-B)法,结果采用WHONET5.6进行分析。结果:2013—2015年共检出金黄色葡萄球菌1 725株,主要来源于痰液(35.4%),在ICU(43.7%)和神经外科(12.6%)检出率最高。2013—2015年,耐甲氧西林金黄色葡萄球菌(methicillin-resistant Staphylococcus aureus,MRSA)检出率分别为63.3%,59.8%,57.6%。MRSA耐药率大于50.0%的抗菌药物有庆大霉素(53.2%~73.1%)、妥布霉素(62.8%~64.9%)、环丙沙星(67.2%~75.3%)、红霉素(86.6%~92.9%)、四环素(53.5%~65.0%);甲氧西林敏感金黄色葡萄球菌(methicillin-sensitive Staphylococcus aureus,MSSA)对抗生素的耐药率排在前3位的为青霉素(85.4%~93.3%)、红霉素(68.7%~72.4%)、复方新诺明(46.3%~57.9%)。结论:本院分离的金黄色葡萄球菌主要分布在ICU和神经外科,MRSA的耐药率普遍较高,临床医生应根据耐药性合理选用抗菌药物。


Clinical distribution and drug resistance of Staphylococcus aureus from 2013 to 2015

Abstract

Objective: To analyze the clinical distribution and drug resistance from 2013 to 2015 in Affiliated Hospital of Xuzhou Medical University, so as to provide reasonable treatment for clinical antibiotic microbiota. Methods: The Staphylococcus aureus (S. aureus) strains isolated from various specimens from Jan 1, 2013 to Dec 31, 2015 were collected, then the drug susceptibility testing of the clinical isolates was performed with Kirby-Bauer diffusion method. Data were analyzed by the WHONET5.6 software. Results: A total of 1 725 strains of S. aureus were isolated from 2013 to 2015. The S. aureus strains were mainly isolated from sputum specimens (35.4%), and the positive-specimens were mostly derived from ICU (43.7%) and neurosurgery (12.6%). From 2013 to 2015, the constituent ratio of methicillin-resistant Staphylococcus aureus (MRSA) was 63.3%, 59.8% and 57.6%, respectively. The drug resistance rate of MRSA for many antibiotics greater than 50.0% included gentamicin (53.2%—73.1%), tobramycin (62.8%—64.9%), ciprofloxacin (67.2%—75.3%), erythromycin (86.6%—92.9%) and tetracycline (53.5%~65.0%). And, interestingly, the top 3 of the drug resistance of methicillin-sensitive Staphylococcus aureus (MSSA) were penicillin (85.4%—93.3%), erythromycin (68.7%—72.4%) and sulfamethoxazole-trimethoprim (46.3%—57.9%). Conclusion: The isolated S. aureus distributes mainly in ICU and the department of neurosurgery. What’s more, the MRSA strains are highly resistant commonly. Doctors should choose the suitable antibiotics according to the fact of drug resistance.


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引用

引用本文: 玥 汪, 婷婷 秦, 帅 纵, 海全 康, 丽华 邓, 萍 马, 银海 徐, 兵 顾. 2013—2015年金黄色葡萄球菌的临床分布及耐药性分析[J]. 临床与病理杂志, 2016, 36(12): 1996-2001.
Cite this article as: WANG Yue, QIN Tingting, ZONG Shuai, KANG Haiquan, DENG Lihua, MA Ping, XU Yinhai, GU Bing . Clinical distribution and drug resistance of Staphylococcus aureus from 2013 to 2015[J]. Journal of Clinical and Pathological Research, 2016, 36(12): 1996-2001.