论著 Original Article

刺五加注射液合并氟西汀治疗阿尔茨海默病伴发抑郁的效果

Published at: 2017年第37卷第1期

石雁 1 , 陈勇新 2
1 广东药科大学附属第一医院老年科,广州 510080
2 中山大学附属肿瘤医院影像介入科,广州 510060
通讯作者 雁 石 Email: swednz@sina.com
DOI: 10.3978/j.issn.2095-6959.2017.01.011
基金:

摘要

目的:探讨刺五加注射液合并氟西汀治疗阿尔茨海默病伴发抑郁的效果。方法:选取广东药科大学附属第一医院2014年1月至2015年9月收治的90例阿尔茨海默病并发抑郁患者,采用随机数字表法将这些患者均分为研究组与对照组。研究组患者采用刺五加注射液和氟西汀联合治疗,对照组患者仅采用氟西汀进行治疗。采用汉密尔顿抑郁量表(Hamilton Depression Scale,HAMD)评分表、疾病自我管理效能测量表及WHO生存质量测定量表(WHO quality of life scale,WHO QOL-BREF)对患者进行入院时、出院时的抑郁和生活质量进行评价;比较两组患者治疗前后帕金森氏病综合评分量表(Unified Parkinson’s Disease Rating Scale,UPDRS)评分和过程中的不良反应发生情况。结果:所有患者在入院时的HAMD,QOL-BREF评分均偏高且无统计学差异(P>0.05);在出院时,研究组和对照组患者的HAMD,QOL-BREF评分均不同程度地下降,但组间数据有统计学差异(P<0.05);治疗前,两组患者的UPDRS评分无明显差异(P>0.05),而经过治疗后研究组患者的UPDRS评分明显低于对照组患者(P<0.05);两组患者的不良反应发生情况并无统计学差异(P>0.05)。结论:刺五加注射液联合氟西汀对阿尔茨海默病有良好的缓解和治疗效果,目前国内对此研究较少,且两药合用对于阿尔茨海默病患者的生活质量进一步提高亦具有良好的临床意义。


Effect of acanthopanex injection combined with fluoxetine in the treatment of senile dementia with depression

Abstract

Objective: To investigate the effect of injection combined with fluoxetine in the treatment of senile dementia with depression. Methods: Ninety cases of senile dementia complicated with depression were selected from January 2014 to September 2015 in The First Hospital Affiliated to Guangdong Pharmaceutical University. The patients were divided into the study group and the control group by the random number table method. Patients in the study group were treated with combination therapy of injection and fluoxetine, and the control group was treated with fluoxetine only. We evaluated the depression and quality of life when the patients were admitted to the hospital and leave hospital by Hamilton Depression Scale (HAMD), disease self-management efficiency measuring table and the WHO quality of life scale (QOL-BREF). Compared the incidence of adverse reactions and Unified Parkinson’s Disease Rating Scale (UPDRS) in the two groups before and after the treatment. Results: HAMD, QOL-BREF scores were high in all patients on admission to hospital and have no statistical difference (P>0.05); when discharged from hospital, HAMD, QOL-BREF scores of the study group and the control group of patients declined in different degree, but data between the groups have significant difference (P<0.05); before treatment, there was no significant difference in the UPDRS score between the two groups (P>0.05), after treatment the UPDRS score of the study group was significantly lower than that in the control group (P<0.05); there was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion: Thorn slender acanthopanax injection combined with fluoxetine has good remission and effect in treatment of senile dementia, and their combination has a good clinical significance for the quality of life of elderly patients with dementia.


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引用本文: 雁 石, 勇新 陈. 刺五加注射液合并氟西汀治疗阿尔茨海默病伴发抑郁的效果[J]. 临床与病理杂志, 2017, 37(1): 56-61.
Cite this article as: SHI Yan, CHEN Yongxin . Effect of acanthopanex injection combined with fluoxetine in the treatment of senile dementia with depression[J]. Journal of Clinical and Pathological Research, 2017, 37(1): 56-61.