论著 Original Article

成骨细胞特异性转录因子2在乳腺癌中的表达及临床意义

Published at: 2017年第37卷第1期

周炳娟 1,2 , 黄丽娟 2 , 曹建江 2 , 马小乐 2 , 孙吉瑞 1 , 乔海芝 1 , 赵文明 1 , 张金库 1
1 保定市第一中心医院病理科,河北 保定 071000
2 新疆生产建设兵团第二师库尔勒医院病理科,新疆 库尔勒 841000
通讯作者 金库 张 Email: zjkblk@sohu.com
DOI: 10.3978/j.issn.2095-6959.2017.01.010
基金:

摘要

目的:探讨成骨细胞特异性转录因子2(runt-related transcription factor 2,Runx2)在乳腺癌组织中的表达及临床意义。方法:采用免疫组织化学法检测Runx2在乳腺浸润性导管癌和癌旁乳腺组织中的表达情况及其与乳腺癌临床病理特征间的关系。结果:Runx2在乳腺浸润性导管癌及癌旁乳腺组织中的阳性表达率分别为69.52%(73/105)和8.57%(9/105),乳腺浸润性导管癌组Runx2的阳性表达率显著高于癌旁乳腺组织,差异具有统计学意义,而且Runx2在乳腺浸润性导管癌中的表达与雌激素受体(estrogen receptor,ER)呈负相关。Runx2的表达与乳腺癌的组织学分级、淋巴结转移及临床分期相关,而与患者年龄及肿瘤大小无关。结论:Runx2可能参与了乳腺癌的发生,而且在ER阴性乳腺癌的发生过程中可能发挥了更加重要的作用。Runx2与乳腺癌的恶性程度、浸润、转移有关,提示Runx2可能成为乳腺癌患者预后评估的重要指标之一。


Expression and clinical significance of runt-related transcription factor 2 in breast carcinoma

Abstract

Objective: To study the expression and clinical significance of runt-related transcription factor 2 (Runx2) in breast carcinoma. Methods: The expression of Runx2 in primary breast invasive ductal carcinoma (IDC) and adjacent mammary gland tissue and its relationship with breast cancer’s clinical pathological features was detected by immunohistochemical method (IHC). Results: IHC analysis showed that the positive expression rate of Runx2 in IDC was 69.52% (73/105), much higher than that in para-tumor breast tissues [8.57% (9/105), P<0.05] and the expression of Runx2 in IDC was negatively related with estrogen receptor (ER). Furthermore, Runx2 expression showed a significant correlation with histopathologic grade lymph node metastasis and pTNM stage, and did not correlate with patients’ age, and tumor size. Conclusion: The overexpression of Runx2 may participate in the tumorigenesis of breast carcinoma and may play a more important role in the carcinogenesis of ER negative-expressing breast carcinoma. Runx2 correlated with malignant degree, invasion and metastasis of breast carcinoma and may be a key factor to assess the prognosis of patients.


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引用

引用本文: 炳娟 周, 丽娟 黄, 建江 曹, 小乐 马, 吉瑞 孙, 海芝 乔, 文明 赵, 金库 张. 成骨细胞特异性转录因子2在乳腺癌中的表达及临床意义[J]. 临床与病理杂志, 2017, 37(1): 50-55.
Cite this article as: ZHOU Bingjuan, HUANG Lijuan, CAO Jianjiang, MA Xiaole, SUN Jirui, QIAO Haizhi, ZHAO Wenming, ZHANG Jinku . Expression and clinical significance of runt-related transcription factor 2 in breast carcinoma[J]. Journal of Clinical and Pathological Research, 2017, 37(1): 50-55.