论著 Original Article

20例梭形细胞癌的病理形态及免疫组织化学特征

Published at: 2017年第37卷第1期

李晶 1
1 广州金域医学检验中心有限公司实验诊断部病理科,广州 510330
通讯作者 晶 李 Email: sumslij@126.com
DOI: 10.3978/j.issn.2095-6959.2017.01.008
基金:

摘要

目的:探讨梭形细胞癌的形态学及免疫组织化学特征及鉴别诊断。方法:收集20例梭形细胞癌病例的临床及病理资料,分析其形态学特征及免疫表型特征。结果:20例梭形细胞癌中男性12例,女性8例,平均年龄62.5岁。肿瘤无器官特异性,肿瘤细胞呈梭形,多数病例异型性明显,少数病例细胞温和,异形性不明显。免疫组织化学示肿瘤细胞均表达vimentin;至少表达一种上皮标志物;CK,34βE12,CK5/6,EMA和P63阳性率较高;常表达desmin,calponin,SMA;不表达CD34,S100,HMB-45,myogenin,MyoD1,ALK。结论:梭形细胞癌是一种具有独特形态学和免疫表型的肿瘤。


Morphological and immunohistochemical features in 20 cases of spindle cell carcinoma

Abstract

Objective: To investigate the morphological and immunohistochemical features and differential diagnosis of spindle cell carcinoma. Methods: The clinical and pathological data of 20 cases of spindle cell carcinoma were collected, and the morphological characteristics and immunohistochemical features were analyzed. Results: Among the 20 cases of spindle cell carcinoma, 12 were male and 8 were female. The mean age was 62.5 years. Tumor cells were fusiform while tumor was not organ specificity, most cases were pleomorphism which is not obvious, a few mild cases of cells. Immunohistochemistry revealed that vimentin was positive in all cases, at least one of epithelial markers was positive. CK, 34βE12, CK5/6, EMA and p63 had higher positive rate. And desmin, calponin, SMA were positive in many cases. CD34, S-100, HMB-45, myogenin, MyoD1, ALK were negative in all cases. Conclusion: Spindle cell carcinoma is a kind of tumor with special morphology and immune phenotype.


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引用

引用本文: 晶 李. 20例梭形细胞癌的病理形态及免疫组织化学特征[J]. 临床与病理杂志, 2017, 37(1): 41-44.
Cite this article as: LI Jing . Morphological and immunohistochemical features in 20 cases of spindle cell carcinoma[J]. Journal of Clinical and Pathological Research, 2017, 37(1): 41-44.