Morphological and immunohistochemical features in 20 cases of spindle cell carcinoma
Objective: To investigate the morphological and immunohistochemical features and differential diagnosis of spindle cell carcinoma. Methods: The clinical and pathological data of 20 cases of spindle cell carcinoma were collected, and the morphological characteristics and immunohistochemical features were analyzed. Results: Among the 20 cases of spindle cell carcinoma, 12 were male and 8 were female. The mean age was 62.5 years. Tumor cells were fusiform while tumor was not organ specificity, most cases were pleomorphism which is not obvious, a few mild cases of cells. Immunohistochemistry revealed that vimentin was positive in all cases, at least one of epithelial markers was positive. CK, 34βE12, CK5/6, EMA and p63 had higher positive rate. And desmin, calponin, SMA were positive in many cases. CD34, S-100, HMB-45, myogenin, MyoD1, ALK were negative in all cases. Conclusion: Spindle cell carcinoma is a kind of tumor with special morphology and immune phenotype.