目的：观察活性氧联合玻璃酸钠治疗膝关节退行性骨关节炎(degenerative osteoarthritis，DOA)的疗效。方法：选取我院2012年6月至2014年6月收治的176例膝关节DOA患者，按照随机数字表分为观察组及对照组，各88例，进行前瞻性对照研究。两组患者均接受玻璃酸钠关节腔注射治疗，观察组加用医用臭氧关节腔注入。比较两组患者治疗效果、关节功能变化及不良反应。结果：两组患者治疗后疼痛视觉模拟量表(visual analogue scale，VAS)评分均显著降低，并于治疗6个月后逐渐上升，观察组治疗后各时期VAS评分均显著低于对照组(P<0.05)。两组患者治疗5周后膝关节Lequesne指数评分、关节压痛值均显著降低，关节活动度均显著升高，观察组变化更为明显(P<0.05)。观察组临床总有效率为92.0%，显著高于对照组的73.9%(P<0.05)。176例患者均一次性穿刺成功，两组患者均未见感染、明显全身不良反应发生。结论：活性氧联合玻璃酸钠能够有效改善膝关节DOA患者疼痛及膝关节功能，具有良好的临床疗效及安全性，值得进一步推广。
Observation on the therapeutic effect of reactive oxygen combined with sodium hyaluronate in the treatment of knee degenerative osteoarthritis
Objective: To observe the effect of reactive oxygen combined with sodium hyaluronate in the treatment of knee degenerative osteoarthritis (DOA). Methods: 176 cases of patients with knee joint DOA in our hospital from June 2012 to June 2014 were selected. According to random number table for the qualified subjects prospective randomized clinical research, the patients were divided into observation group and control group, 88 cases for each. The control group were treated with sodium hyaluronate injection, and the observation group was treated with medical ozone injection. The therapeutic effect, joint function and adverse reactions of the two groups were compared. Results: The visual analogue scale (VAS) score of two groups of patients after treatment were significantly lower, and increased gradually after 6 months of treatment, the observation group’s VAS score were significantly lower than the control group (P<0.05) after treatment. 5 weeks after treatment, the Lequesne index and the tenderness of the knee joint of two groups decreased significantly, the activity of the joint increased significantly, and the change of the observation group was more significant (P<0.05). The clinical total effective rate in the observation group was 92%, which was significantly higher than that in the control group (P<0.05). Conclusion: Reactive oxygen species combined with sodium hyaluronate can effectively improve pain situation and knee joint function of patients with knee DOA, which has good clinical efficacy, is safety and worthy of further promotion.