综述 Review

人工髓核材料的研究进展

Published at: 2016年第36卷第10期

杨斐 1 , 徐海栋 1 , 许斌 1 , 赵建宁 1
1 南京大学医学院临床学院(南京军区南京总医院)骨科,南京 210000
通讯作者 建宁 赵 Email: zhaojianning.0207@163.com
DOI: 10.3978/j.issn.2095-6959.2016.10.041
基金:
国家自然科学基金项目资助 81501925

摘要

椎间盘退变性疾病是一种临床常见疾病,40%的下腰背疼痛是由腰椎间盘退变引起的。临床手术治疗只能在短期内缓解症状,无法达到根治的目的。在髓核摘除术后,人工髓核组织材料包括最早的硅橡胶、不锈钢和现在使用的水凝胶材料被用来填补病变的髓核组织,维持椎间盘足够的高度。随着组织工程和材料科学的不断发展,有希望使用干细胞或多能细胞来修复病变椎间盘或逆转其退变过程,重塑椎间盘的生理功能。现阶段组织工程仍然需要面临的问题是能否找到一种近似于髓核组织结构和功能的细胞外支架,为种子细胞的生长和生理活动提供合适的环境。文章就人工髓核材料的发展历史以及目前的研究情况展开综述。


Advances in prosthetic disc nucleus material

Abstract

Degenerative disc disease is very common in clinical, and 40% of low back pain is caused by lumbar disc degeneration. Clinical surgery can relieve symptoms in the short term, but it cannot achieve the purpose of cure. In discectomy surgery, the artificial nucleus pulposus material such as silicone rubber, stainless steel, and hydrogel material is used to fill the defect of nucleus pulposus, in order to maintain a sufficient height of disc. With the continuous development of tissue engineering and materials science, it will be possible to use stem cells or multipotent cells to cure disc disease, and to restore the physiological function of the intervertebral disc. Now the problem that tissue engineering still has to face is how to find an extracellular scaffold which has similar structure and function of the nucleus pulposus to provide a suitable environment for the growth and physiological activity of nucleus pulposus cells. The article reviews the history of the development of artificial nucleus material and the current research situation.


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引用

引用本文: 斐 杨, 海栋 徐, 斌 许, 建宁 赵. 人工髓核材料的研究进展[J]. 临床与病理杂志, 2016, 36(10): 1683-1688.
Cite this article as: YANG Fei, XU Haidong, XU Bin, ZHAO Jianning . Advances in prosthetic disc nucleus material[J]. Journal of Clinical and Pathological Research, 2016, 36(10): 1683-1688.