The correlation between the expression level of STC1 and the pathological parameters of breast cancer metastasis and chemotherapy resistance
Objective: To investigate the correlation between the expression level of human stanniocalcin 1 (STC1) and the pathological parameters of breast cancer metastasis and chemotherapy resistance. Methods: The expression levels of STC1 in 76 breast cancer tissues were analyzed by immunohistochemistry, and the relationship between the expression levels and pathological parameters such as metastasis and chemotherapy resistance were studied. Results: In 76 cases of breast cancer, 33 cases of positive expression and 43 cases of negative expression. There was no significant difference in the age, tumor diameter and stage between the two groups (P>0.05), but there were significant difference between the two groups in the incidence of metastasis and chemotherapy resistance (P<0.05). Pearson correlation coefficient test confirmed that the expression level of STC1 was positively correlated with the rate of metastasis and chemotherapy resistance (r=0.413; r=0.359). Conclusion: The expression of human calcium 1 is related to the metastasis and chemotherapy resistance of breast cancer. It is a reference index for prognosis prediction.