论著 Original Article

老年慢性阻塞性肺疾病急性期合并肺结核感染的治疗方法及其疗效探讨

Published at: 2016年第36卷第10期

石菡 1
1 成都医学院第一附属医院感染科,成都 610500
通讯作者 菡 石 Email: shihan0387@sina.com
DOI: 10.3978/j.issn.2095-6959.2016.10.032
基金:

摘要

目的:探讨老年慢性阻塞性肺疾病(chronic obstructive lung disease,COPD)急性期合并肺结核感染的治疗方法及其疗效。方法:选取2014年2月至2016年2月我院收治的老年慢性阻塞性肺疾病急性期合并肺结核感染的患者92例,根据治疗方式随机分为治疗组和对照组,对照组给予COPD对症支持治疗和抗肺结核治疗,治疗组在对照组基础上加用痰热清,比较两组患者治疗有效率、痰培养阴转率以及肝肾损害情况的差异。结果:治疗组患者治疗后痰培养阴转率(36例,85.71%)与对照组(41例,82.0%)的差异无统计学意义(P>0.05)。两组患者治疗后的症状积分均低于治疗前,且差异具有统计学差异(P<0.05),治疗组治疗后的症状积分(85.62±11.37)低于对照组(91.25±12.38),且差异具有统计学差异(P<0.05)。治疗组治疗后痊愈2例(4.76%),显效26例(61.90%),有效10例(23.81%),无效4例(9.52%);对照组治疗后痊愈1例(2.0%),显效17例(34.0%),有效22例(44.0%),无效10例(20.0%);治疗组治疗疗效明显优于对照组,且差异具有统计学意义(P<0.05)。治疗组治疗后发生肝肾损害14例,对照组11例,两组患者治疗后肝肾损害发生率的差异无统计学意义(P>0.05)。结论:在不影响痰培养阴转率和不加重肝肾负担的情况下,老年COPD急性期合并肺结核感染患者接受一般性治疗的同时进行中医治疗,其疗效更为显著。


The treatment method and curative effect of pulmonary tuberculosis infection in elderly patients with acute chronic obstructive lung disease

Abstract

Objective: To investigate the treatment method and curative effect of pulmonary tuberculosis infection in elderly patients with acute chronic obstructive lung disease (COPD). Methods: Selected 92 cases of elderly patients with COPD complicated with pulmonary tuberculosis in our hospital from February 2014 to February 2016, and randomly divided into treatment group and control group according to the treatment method. The two groups were treated with the same clinical therapy included COPD symptomatic and supportive treatment and anti-tuberculosis treatment. Besides, the treatment group was given Tanreqing. Compared the treatment efficiency, sputum culture negative conversion rate and the difference of liver and kidney damage between the two groups. Results: There was no significant difference in sputum culture negative conversion rate between the treatment group (36 cases, 85.71%) and the control group (41 cases, 82%) after treatment. Symptom scores of two groups after treatment were lower than those before treatment, and the difference was statistically significant (P<0.05), the symptom scores (85.62±11.37) in treatment group after treatment were lower than those in control group (12.38±91.25), and the difference was statistically significant (P<0.05). In the treatment group after treatment, 2 cases (4.76%) were cured, 26 cases were markedly effective (61.90%), 10 cases were effective (23.81%), and 4 cases (9.52%) were ineffective; in the control group, 1 cases (2%) were cured, 17 cases (34%) were markedly effective, 22 cases (44%) were effective, and 10 cases (20%) were ineffective; the efficiency in the treatment group was significantly better than that in the control group, and the difference was statistically significant (P<0.05). 14 cases occurred liver and kidney damage in the treatment group after the treatment, and 11 cases in the control group, there was no significant difference in the incidence of liver and kidney damage after treatment between the two groups (P>0.05). Conclusion: Without affecting the sputum culture negative conversion rate and increasing the burden of liver and kidney, traditional Chinese medicine treatment of the elderly patients with acute COPD complicated with pulmonary tuberculosis infection in general treatment, the curative effect was more significant.


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引用

引用本文: 菡 石. 老年慢性阻塞性肺疾病急性期合并肺结核感染的治疗方法及其疗效探讨[J]. 临床与病理杂志, 2016, 36(10): 1634-1639.
Cite this article as: SHI Han . The treatment method and curative effect of pulmonary tuberculosis infection in elderly patients with acute chronic obstructive lung disease[J]. Journal of Clinical and Pathological Research, 2016, 36(10): 1634-1639.